Time-dependent association between selective serotonin reuptake inhibitors and hospitalization due to hyponatremia
| العنوان: | Time-dependent association between selective serotonin reuptake inhibitors and hospitalization due to hyponatremia |
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| المؤلفون: | Jakob Skov, Jonatan D. Lindh, Henrik Falhammar, Jan Calissendorff, Buster Mannheimer |
| المصدر: | Journal of Psychopharmacology (Oxford, England) |
| بيانات النشر: | SAGE Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Time Factors, Adolescent, hyponatremia, adverse reaction, 030204 cardiovascular system & hematology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, SSRI, Pharmacology (medical), Registries, 030212 general & internal medicine, Adverse effect, sodium, Depression (differential diagnoses), Aged, Retrospective Studies, Aged, 80 and over, Sweden, Pharmacology, Syndrome of inappropriate antidiuretic hormone secretion, business.industry, nutritional and metabolic diseases, Middle Aged, Serotonin reuptake, medicine.disease, Original Papers, Hospitalization, Psychiatry and Mental health, Increased risk, Endocrinology, Case-Control Studies, Anxiety, Female, medicine.symptom, Hyponatremia, business, Selective Serotonin Reuptake Inhibitors |
| الوصف: | Background: Selective serotonin reuptake inhibitors (SSRIs) have a wide and increasing use for the treatment of depression and anxiety. Previous studies have indicated an increased risk of hyponatremia during the first months of treatment. We aimed to investigate the detailed time-course of SSRI-associated hyponatremia with a high temporal resolution, using registry data encompassing the total Swedish population. Methods: This was a population-based case control study using several national registers. Patients hospitalized with a principal diagnosis of hyponatremia ( n = 11,213) were compared with matched controls ( n = 44,801). Multivariable regression was applied to explore time-dependent associations between SSRIs and hospitalization due to hyponatremia. Results: Individuals initiating treatment with SSRIs were exposed to an immediately increased risk for hospitalization at week 1, reaching an adjusted odds ratio (aOR) (95% confidence interval) of 29 (19–46). The associations then gradually declined, reaching an aOR of 2.1 (1.0–4.2) by week 13. The aOR for individuals treated for longer than 13 weeks was 0.78 (0.71–0.85). Conclusions: This study revealed a dramatically increased risk of hyponatremia exclusively related to newly initiated treatment. Consequently, even subtle symptoms consistent with hyponatremia during the first weeks of SSRI treatment should prompt analysis of sodium levels. In patients treated with SSRIs for several months or years, other causes should primarily be sought in the event of hyponatremia. |
| تدمد: | 1461-7285 0269-8811 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300edc3f19eb46a0816832d62eb8060d https://doi.org/10.1177/02698811211001082 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....300edc3f19eb46a0816832d62eb8060d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14617285 02698811 |
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