Effect of naringerin on biochemical parameters in the streptozotocin-induced diabetic rats
| العنوان: | Effect of naringerin on biochemical parameters in the streptozotocin-induced diabetic rats |
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| المؤلفون: | Ethel L. B. Novelli, Cristiano M. Galhardi, Ana Angélica Henrique Fernandes, Ary Fernandes Júnior |
| المساهمون: | Universidade Estadual Paulista (Unesp) |
| المصدر: | Brazilian Archives of Biology and Technology, Vol 52, Iss 1, Pp 51-59 (2009) Brazilian Archives of Biology and Technology v.52 n.1 2009 Brazilian Archives of Biology and Technology Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR Brazilian Archives of Biology and Technology, Volume: 52, Issue: 1, Pages: 51-59, Published: FEB 2009 SciELO Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| بيانات النشر: | Instituto de Tecnologia do Paraná (Tecpar), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | medicine.medical_specialty, Multidisciplinary, hypoglycaemic activity, business.industry, aminotransferases, lcsh:Biotechnology, nutritional and metabolic diseases, Streptozotocin, medicine.disease, streptozotocin, Naringerin, Endocrinology, Internal medicine, Diabetes mellitus, lcsh:TP248.13-248.65, diabetes mellitus, medicine, cardiac tissues, business, hepatic, medicine.drug |
| الوصف: | Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:40:56Z No. of bitstreams: 1 S1516-89132009000100007.pdf: 93111 bytes, checksum: c466edb67d49dd56d786eddffcc3291d (MD5) Made available in DSpace on 2013-08-22T18:40:56Z (GMT). No. of bitstreams: 1 S1516-89132009000100007.pdf: 93111 bytes, checksum: c466edb67d49dd56d786eddffcc3291d (MD5) Previous issue date: 2009-02-01 Made available in DSpace on 2013-09-30T19:27:09Z (GMT). No. of bitstreams: 2 S1516-89132009000100007.pdf: 93111 bytes, checksum: c466edb67d49dd56d786eddffcc3291d (MD5) S1516-89132009000100007.pdf.txt: 39715 bytes, checksum: be041c9615b555ce5dc12c7aaf11d964 (MD5) Previous issue date: 2009-02-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:53:24Z No. of bitstreams: 2 S1516-89132009000100007.pdf: 93111 bytes, checksum: c466edb67d49dd56d786eddffcc3291d (MD5) S1516-89132009000100007.pdf.txt: 39715 bytes, checksum: be041c9615b555ce5dc12c7aaf11d964 (MD5) Made available in DSpace on 2014-05-20T13:53:24Z (GMT). No. of bitstreams: 2 S1516-89132009000100007.pdf: 93111 bytes, checksum: c466edb67d49dd56d786eddffcc3291d (MD5) S1516-89132009000100007.pdf.txt: 39715 bytes, checksum: be041c9615b555ce5dc12c7aaf11d964 (MD5) Previous issue date: 2009-02-01 Dentre as numerosas terapias para minimizar as complicações diabéticas, os antioxidantes e flavonoides são testados na clínica médica. Foi analisado o efeito da naringerina sobre os parâmetros bioquímicos em ratos diabéticos induzidos por estreptozotocina (STZ - 60mg/kg, i.p.). Ratos machos foram divididos em 4 grupos: G1: controle não tratado; G2: ratos normais que receberam naringerina; G3: diabéticos não tratados; G4: ratos diabéticos que receberam naringerina. Naringerina (50mg/kg, i.p.), decresceu a hiperglicemia e a hiperlipidemia em ratos diabéticos. A concentração sérica de insulina em ratos tratados tendeu aumentar. A naringerina preveniu as alterações, provocadas pela estreptozotocina, na atividade hepática e cardíaca de ALT, AST e LDH, indicando o efeito protetor da naringerina sobre estes tecidos, contra toxicidade provocada pela STZ. O nível de glicogênio nos tecidos cardíaco e hepático elevou com a naringerina em ratos diabéticos. A naringerina melhorou o metabolismo da glicose e de lipídios e preveniu as complicações diabéticas. Amongst the numerous co-adjuvant therapies which could influence the incidence and progression of diabetic complications, antioxidants and flavonoids are currently being tested in clinical trials. We investigated the effect of naringerin on biochemical parameters in streptozotocin-induced (STZ - 60 mg/kg, i.p.) diabetic rats. Male rats were divided into four groups: G1: untreated controls; G2: normal rats receiving naringerin; G3: untreated diabetics; G4: diabetics rats receiving naringerin. The naringerin (50mg/kg, i.p,) decreased the hyperglycaemia and hyperlipidaemia associated with STZ-diabetes. The concentrations of serum insulin in treated diabetic rats tended to be increased. Naringerin treatment prevents STZ-induced changes in the activities of ALT, AST and LDH in the liver and heart, indicating the protective effect of naringerin against the hepatic and cardiac toxicity caused by STZ. The glycogen level in cardiac and hepatic tissues elevated with naringerin in diabetic rats. The naringerin can improve the glucose and lipid metabolism and is beneficial in preventing diabetic complications. Universidade Estadual Paulista Instituto de Biociências Departamento de Química e Bioquímica Universidade Estadual Paulista Instituto de Biociências Departamento de Microbiologia e Imunologia Universidade Estadual Paulista Instituto de Biociências Departamento de Química e Bioquímica Universidade Estadual Paulista Instituto de Biociências Departamento de Microbiologia e Imunologia |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 1678-4324 1516-8913 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303fe1a9e1fcde6b3305d876a0f1ccf3 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000100007 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....303fe1a9e1fcde6b3305d876a0f1ccf3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16784324 15168913 |
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