The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical trials
| العنوان: | The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical trials |
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| المؤلفون: | Ubaka Ogbogu, Daniel Strech, Mark A Yarborough, Emily S. Sena, Nanette C. Joyce, Ulrich Dirnagl, Flavio D'Abramo, Annelien L. Bredenoord, Jonathan Kimmelman |
| المصدر: | PLoS biology, vol 16, iss 6 PLoS Biology Yarborough, M, Bredenoord, A, D'Abramo, F, Joyce, N C, Kimmelman, J, Ogbogu, U, Sena, E, Strech, D & Dirnagl, U 2018, ' The bench is closer to the bedside than we think : Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical trials ', PLoS Biology, vol. 16, no. 6, pp. e2006343 . https://doi.org/10.1371/journal.pbio.2006343 PLoS Biology, 16(6). Public Library of Science Yarborough, M; Bredenoord, A; D’Abramo, F; Joyce, NC; Kimmelman, J; Ogbogu, U; et al.(2018). The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical trials. PLoS Biology, 16(6). doi: 10.1371/journal.pbio.2006343. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/46r9786t PLoS Biology, Vol 16, Iss 6, p e2006343 (2018) |
| بيانات النشر: | eScholarship, University of California, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Research Validity, Biomedical, Psychological intervention, Publication Ethics, Biochemistry, Vascular Medicine, Medical and Health Sciences, Motor Neuron Diseases, Translational Research, Biomedical, Preclinical research, 0302 clinical medicine, Medicine and Health Sciences, Biology (General), Translational Medical Research, Research Integrity, media_common, Clinical Trials as Topic, Agricultural and Biological Sciences(all), General Neuroscience, Cultural, Gender, and Political Contexts of Science, Neurodegenerative Diseases, Research Assessment, Biological Sciences, Stroke, Neurology, Perspective, Neurological, Research Reporting Guidelines, Engineering ethics, General Agricultural and Biological Sciences, Medical Ethics, Drug Research and Development, QH301-705.5, Science Policy, Neuroscience(all), media_common.quotation_subject, Cerebrovascular Diseases, MEDLINE, Biology, Research and Analysis Methods, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Clinical Research, Immunology and Microbiology(all), Translational Research, Animals, Humans, Quality (business), Clinical Trials, Pharmacology, General Immunology and Microbiology, Agricultural and Veterinary Sciences, Biochemistry, Genetics and Molecular Biology(all), Amyotrophic Lateral Sclerosis, Neurosciences, Publication bias, Clinical trial, 030104 developmental biology, Clinical Medicine, Nervous System Diseases, Safety Studies, Publication Bias, 030217 neurology & neurosurgery, Translational neuroscience, Medical ethics, Genetics and Molecular Biology(all), Developmental Biology |
| الوصف: | © 2018 Yarborough et al. http://creativecommons.org/licenses/by/4.0/ Millions of people worldwide currently suffer from serious neurological diseases and injuries for which there are few, and often no, effective treatments. The paucity of effective interventions is, no doubt, due in large part to the complexity of the disorders, as well as our currently limited understanding of their pathophysiology. The bleak picture for patients, however, is also attributable to avoidable impediments stemming from quality concerns in preclinical research that often escape detection by research regulation efforts. In our essay, we connect the dots between these concerns about the quality of preclinical research and their potential ethical impact on the patients who volunteer for early trials of interventions informed by it. We do so in hopes that a greater appreciation among preclinical researchers of these serious ethical consequences can lead to a greater commitment within the research community to adopt widely available tools and measures that can help to improve the quality of research. |
| وصف الملف: | application/pdf; image/pdf |
| تدمد: | 1544-9173 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d0ab20e1df00fd2e5d2efe2c59ed3b https://escholarship.org/uc/item/46r9786t |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....30d0ab20e1df00fd2e5d2efe2c59ed3b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15449173 |
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