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Human leukocyte antigens in 295 Chinese patients with chronic myeloid leukemia

التفاصيل البيبلوغرافية
العنوان: Human leukocyte antigens in 295 Chinese patients with chronic myeloid leukemia
المؤلفون: Xin Zhou, Qin-Qin Pan, X.M. Fei, M. Xue, C. Y. Wang, Meng Pan, Su Fan, Kou-Rong Miao, Xiao-Yan Wang, Xing Zhao
المصدر: Leukemia & Lymphoma. 48:2152-2156
بيانات النشر: Informa UK Limited, 2007.
سنة النشر: 2007
مصطلحات موضوعية: Adult, China, Cancer Research, Adolescent, Population, Human leukocyte antigen, Biology, Gene Frequency, HLA Antigens, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, medicine, Humans, Genetic Predisposition to Disease, Allele, Child, education, Allele frequency, Aged, education.field_of_study, Polymorphism, Genetic, Case-control study, Hematopoietic stem cell, Myeloid leukemia, Hematology, Odds ratio, Middle Aged, medicine.anatomical_structure, Oncology, Case-Control Studies, Child, Preschool, Immunology
الوصف: Experimental studies using synthetic peptides identical to the bcr-abl fusion region in chronic myeloid leukemia (CML) patients have revealed that some specific peptides could bind to human leukocyte antigen (HLA) class I and class II molecules. Previous clinical observations have also reported some significant HLA associations with the development of CML in their populations. Due to high diversity of HLA alleles, the present study assessed the possibility of an association of HLA molecules in CML patients living in Jiangsu province, the eastern part of China. HLA-A, B and DRB1 allele distributions in 295 CML patients (aged 4-65 years) were analysed and compared with unrelated healthy hematopoietic stem cell donors from the same ethnic and geographic background. By comparison of the HLA gene distribution characteristics between CML and healthy donor populations, differences with statistical significance were found in HLA-A*30 (5.42% versus 9.13%) with odds ratio (OR) 0.57, DRB1*07 (8.14% versus 12.51%; OR = 0.62), and B*81 (0.51% versus 0.09%, OR = 5.44). These results suggest that expression of HLA-A*30, DRB1*07 might imply a protective effect on CML acquisition, while B*81 might be associated with CML susceptive factors in our population.
تدمد: 1029-2403
1042-8194
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3118ea6198236969c9051589d96d6cda
https://doi.org/10.1080/10428190701632830
رقم الأكسشن: edsair.doi.dedup.....3118ea6198236969c9051589d96d6cda
قاعدة البيانات: OpenAIRE
الوصف
تدمد:10292403
10428194