High-Resolution Proton Nuclear Magnetic Resonance Spectroscopy in the Detection of Low Molecular Weight Volatiles
| العنوان: | High-Resolution Proton Nuclear Magnetic Resonance Spectroscopy in the Detection of Low Molecular Weight Volatiles |
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| المؤلفون: | Alex A. Pappas, Gary L. Fuller, Jennifer R. Thompson, William H. Porter, Richard H. Gadsden |
| المصدر: | Journal of Analytical Toxicology. 17:273-277 |
| بيانات النشر: | Oxford University Press (OUP), 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Chromatography, Gas, Magnetic Resonance Spectroscopy, Health, Toxicology and Mutagenesis, Analytical chemistry, Alcohol, 1-Propanol, Toxicology, Sensitivity and Specificity, Analytical Chemistry, Acetone, chemistry.chemical_compound, Humans, Environmental Chemistry, Chemical Health and Safety, Chromatography, Ethanol, Chemistry, Methanol, Nuclear magnetic resonance spectroscopy, Molecular Weight, Proton NMR, Gas chromatography, Volatilization |
| الوصف: | Proton nuclear magnetic resonance spectroscopy (1H MRS) has been used to identify ethanol in vivo and to detect other exogenous low molecular weight volatiles in human serum. 1H MRS was used to detect and quantitate 15 human sera containing various concentrations and combinations of ethanol, isopropanol, acetone, and methanol as previously quantitated by headspace gas chromatography. The 1H MRS method was linear for each alcohol. The lowest detectable alcohol concentration was 15 mg/L (peak height equal to three times the signal-to-noise ratio), and 30 mg/L (+/- 10% relative standard deviation) was the lowest level reproducibly quantitated. Within-run and day-to-day coefficients of variation (CV) ranged from 0.8 to 2.0% and 0.9 to 1.2%, respectively, for methanol; 0.5 to 1.9% and 0.6 to 1.3% for acetone; and 0.5 to 1.6% and 0.3 to 2.2% for isopropanol. In all cases, the lowest CVs for a particular compound were obtained for the highest measured concentration (1500 mg/L), and the highest CVs were observed for the lowest concentration (250 mg/L). The 1H MRS method for detection of these volatiles does not require sample pretreatment and is nondestructive, which allows for further analysis by other methods. |
| تدمد: | 1945-2403 0146-4760 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313008371b866cfb71676f11126c167a https://doi.org/10.1093/jat/17.5.273 |
| رقم الأكسشن: | edsair.doi.dedup.....313008371b866cfb71676f11126c167a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19452403 01464760 |
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