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Diallyl trisulfide alleviates chemotherapy sensitivity of ovarian cancer via the AMPK / SIRT1 / PGC1α pathway

التفاصيل البيبلوغرافية
العنوان: Diallyl trisulfide alleviates chemotherapy sensitivity of ovarian cancer via the AMPK / SIRT1 / PGC1α pathway
المؤلفون: Zhaojun Wang, Yi Yan, Yijie Lou, Xiaoyan Huang, Lijian Liu, Zhuofan Weng, Yusheng Cui, Xinyue Wu, Huijun Cai, Xiaohui Chen, Yunxi Ji
المصدر: Cancer Science. 114:357-369
بيانات النشر: Wiley, 2022.
سنة النشر: 2022
مصطلحات موضوعية: Cancer Research, Oncology, General Medicine
الوصف: Platinum-based chemotherapy promotes drug resistance in ovarian cancer. We investigated the anti-chemoresistance characteristics of diallyl trisulfide (DATS) in cisplatin-resistant ovarian cancer cells, in vitro and in vivo. Previous preclinical studies have revealed that DATS regulates distinct hallmark cancer-signaling pathways. The cell cycle pathway is the most investigated signaling pathway in DATS. Additionally, post-DATS treatment has been found to promote proapoptotic capacity through the regulation of intrinsic and extrinsic apoptotic pathway components. In the present study, we found that treating cisplatin-sensitive and cisplatin-resistant ovarian cell lines with DATS inhibited their proliferation and reduced their IC
تدمد: 1349-7006
1347-9032
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3146b6706fbbf22a8f0b8eb8fbcad8a4
https://doi.org/10.1111/cas.15627
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....3146b6706fbbf22a8f0b8eb8fbcad8a4
قاعدة البيانات: OpenAIRE
الوصف
تدمد:13497006
13479032