Feasibility of Velocity‐Selective Arterial Spin Labeling in Breast Cancer Patients for Noncontrast‐Enhanced Perfusion Imaging
العنوان: | Feasibility of Velocity‐Selective Arterial Spin Labeling in Breast Cancer Patients for Noncontrast‐Enhanced Perfusion Imaging |
---|---|
المؤلفون: | Daniele Cohen, Suzanne L Franklin, Marijn van Stralen, Clemens Bos, Henrike G Dankers, Tijmen Korteweg, Isabell K. Bones, Martin N. J. M. Wasser, Matthias J.P. van Osch, Nora Voormolen |
المصدر: | Journal of Magnetic Resonance Imaging Journal of Magnetic Resonance Imaging, 54(4), 1282-1291. WILEY |
بيانات النشر: | Wiley, 2021. |
سنة النشر: | 2021 |
مصطلحات موضوعية: | medicine.medical_specialty, DCE-MRI, Perfusion Imaging, Population, Breast Neoplasms, Perfusion scanning, 030218 nuclear medicine & medical imaging, Lesion, 03 medical and health sciences, breast cancer, 0302 clinical medicine, Vascularity, Breast cancer, ASL, medicine, Humans, Radiology, Nuclear Medicine and imaging, Multislice, Prospective Studies, Breast, Stage (cooking), education, noncontrast enhanced, Research Articles, DCE‐MRI, education.field_of_study, Artifact (error), business.industry, screening, medicine.disease, arterial spin labeling, Feasibility Studies, Female, Spin Labels, Radiology, medicine.symptom, business, Research Article |
الوصف: | Background Dynamic contrast-enhanced (DCE) MRI is the most sensitive method for detection of breast cancer. However, due to high costs and retention of intravenously injected gadolinium-based contrast agent, screening with DCE-MRI is only recommended for patients who are at high risk for developing breast cancer. Thus, a noncontrast-enhanced alternative to DCE is desirable. Purpose To investigate whether velocity selective arterial spin labeling (VS-ASL) can be used to identify increased perfusion and vascularity within breast lesions compared to surrounding tissue. Study type Prospective. Population Eight breast cancer patients. Field strength/sequence A 3 T; VS-ASL with multislice single-shot gradient-echo echo-planar-imaging readout. Assessment VS-ASL scans were independently assessed by three radiologists, with 3-25 years of experience in breast radiology. Scans were scored on lesion visibility and artifacts, based on a 3-point Likert scale. A score of 1 corresponded to "lesions being distinguishable from background" (lesion visibility), and "no or few artifacts visible, artifacts can be distinguished from blood signal" (artifact score). A distinction was made between mass and nonmass lesions (based on BI-RADS lexicon), as assessed in the standard clinical exam. Statistical tests Intra-class correlation coefficient (ICC) for interobserver agreement. Results The ICC was 0.77 for lesion visibility and 0.84 for the artifact score. Overall, mass lesions had a mean score of 1.27 on lesion visibility and 1.53 on the artifact score. Nonmass lesions had a mean score of 2.11 on lesion visibility and 2.11 on the artifact score. Data conclusion We have demonstrated the technical feasibility of bilateral whole-breast perfusion imaging using VS-ASL in breast cancer patients. Evidence level 1 TECHNICAL EFFICACY: Stage 1. |
وصف الملف: | application/pdf |
تدمد: | 1522-2586 1053-1807 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314d843181931727b67bcf59fb6d9130 https://doi.org/10.1002/jmri.27781 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....314d843181931727b67bcf59fb6d9130 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 15222586 10531807 |
---|