Inflammatory Pseudotumor of the Temporal Bone: A Case Series
| العنوان: | Inflammatory Pseudotumor of the Temporal Bone: A Case Series |
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| المؤلفون: | Prashant Raghavan, David J. Eisenman, Timothy Ortlip, Virginia E. Drake, John C. Papadimitriou, Ronna Hertzano, Neil C. Porter |
| المصدر: | Otology & Neurotology. 38:1024-1031 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Granuloma, Plasma Cell, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Temporal bone, Adjuvant therapy, Paralysis, Humans, Medicine, Child, 030223 otorhinolaryngology, Aged, Retrospective Studies, medicine.diagnostic_test, business.industry, Temporal Bone, Magnetic resonance imaging, Middle Aged, Mycophenolic Acid, Facial nerve, Sensory Systems, Treatment Outcome, Otorhinolaryngology, Quality of Life, Inflammatory pseudotumor, Female, Rituximab, Histopathology, Neurology (clinical), Radiology, Bone Diseases, medicine.symptom, Tomography, X-Ray Computed, business, Immunosuppressive Agents, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | Objective Inflammatory pseudotumor of the temporal bone is a benign, idiopathic inflammatory process that is locally invasive and a cause of significant morbidity. This study reviews our experience with seven patients and is currently the largest series to date. Study design Retrospective review from January 1, 2014 to January 1, 2016. Setting Single tertiary medical center. Patients There were five male and two female (n = 7) subjects with a diagnosis of temporal bone inflammatory pseudotumor. The mean age at presentation was 41 years old. The most common presenting symptoms were hearing loss (7/7) and headache (4/7). Four patients demonstrated an inflammatory aural polyp. Two patients experienced facial nerve paralysis. Intervention(s) Seven patients underwent computed tomography and six underwent magnetic resonance imaging. Corticosteroids and antibiotics were the initial treatment of choice. Five patients also underwent surgery. As adjuvant therapy, two patients received Rituximab, one patient received radiation, and one received mycophenolate mofetil. Main outcome measure(s) Clinical courses were followed with focus on symptoms, disease recurrence, duration, and treatment. Mean follow-up was 17.8 months. Results The primary lesions demonstrated T2 hypo-intensity and enhancement as well as diffuse dural thickening on magnetic resonance imaging in five of six patients. Histopathology demonstrated chronic inflammation in the setting of hyalinized fibrosis (7/7). All the patients are currently symptomatically stable. Conclusion Inflammatory pseudotumor of the temporal bone can cause devastating effects on neurological function and quality of life. Recognition of characteristic imaging and histopathology can expedite appropriate treatment. Patients may require chronic steroid therapy. Adjunctive therapy with radiation and immuno-modulation are currently being explored. |
| تدمد: | 1537-4505 1531-7129 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3160fd0545297201daecde12eaabd7c0 https://doi.org/10.1097/mao.0000000000001465 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3160fd0545297201daecde12eaabd7c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15374505 15317129 |
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