Low birth weight is associated with impaired murine kidney development and function
| العنوان: | Low birth weight is associated with impaired murine kidney development and function |
|---|---|
| المؤلفون: | Jonathan Gromis, May M. Rabadi, Edson Jules, Parth Dwivedi, Joseph Zullo, Brian B. Ratliff, Lauren Nesi, David L Payne, Mark Lipphardt, Wasan Abdulmahdi, Eric L. Maranda, Amy Patel, Tala Azar, Kunzah Syed, Michael Shen, Christina Barnett, Oluwadara Nnoli |
| المصدر: | Pediatric Research. 82:340-348 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, 030232 urology & nephrology, Gene Expression, Renal function, Kidney development, Nephron, Kidney, urologic and male genital diseases, Mice, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Internal medicine, medicine, Animals, reproductive and urinary physiology, Renal stem cell, urogenital system, business.industry, Kidney metabolism, Infant, Low Birth Weight, medicine.disease, female genital diseases and pregnancy complications, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Animals, Newborn, Pediatrics, Perinatology and Child Health, Immunology, Cytokines, Female, Chemokines, Renal vesicle formation, business, Glomerular Filtration Rate, Kidney disease |
| الوصف: | BackgroundLow birth weight (LBW) neonates have impaired kidney development that leaves them susceptible to kidney disease and hypertension during adulthood. The study here identifies events that blunt nephrogenesis and kidney development in the murine LBW neonate.MethodsWe examined survival, kidney development, GFR, gene expression, and cyto-/chemokines in the LBW offspring of malnourished (caloric and protein-restricted) pregnant mice.ResultsMalnourished pregnant mothers gave birth to LBW neonates that had 40% reduced body weight and 54% decreased survival. Renal blood perfusion was reduced by 37%, whereas kidney volume and GFR were diminished in the LBW neonate. During gestation, the LBW neonatal kidney had 2.2-fold increased apoptosis, 76% decreased SIX2+ progenitor cells, downregulation of mesenchymal-to-epithelial signaling factors Wnt9b and Fgf8, 64% less renal vesicle formation, and 32% fewer nephrons than controls. At birth, increased plasma levels of IL-1β, IL-6, IL-12(p70), and granulocyte-macrophage colony-stimulating factor in the LBW neonate reduced SIX2+ progenitor cells.ConclusionIncreased pro-inflammatory cytokines in the LBW neonate decrease SIX2+ stem cells in the developing kidney. Reduced renal stem cells (along with the decreased mesenchymal-to-epithelial signaling) blunt renal vesicle generation, nephron formation, and kidney development. Subsequently, the mouse LBW neonate has reduced glomeruli volume, renal perfusion, and GFR. |
| تدمد: | 1530-0447 0031-3998 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a3069d39d868080e967d7901502473 https://doi.org/10.1038/pr.2017.53 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....31a3069d39d868080e967d7901502473 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15300447 00313998 |
|---|