The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal Toxicity
| العنوان: | The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal Toxicity |
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| المؤلفون: | Yung-Chi Cheng, Wing Lam, Shwu-Huey Liu, Elizabeth A. Gullen, Wei Zhang, Zaoli Jiang, Scott Bussom, Fulan Guan |
| المصدر: | Science Translational Medicine. 2 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Apoptosis, Pharmacology, Irinotecan, Proinflammatory cytokine, Wnt3 Protein, Mice, Proliferating Cell Nuclear Antigen, Wnt3A Protein, Weight Loss, Biomarkers, Tumor, Animals, Humans, Transplantation, Homologous, Medicine, Medicine, Chinese Traditional, beta Catenin, Cell Proliferation, Glucuronidase, Inflammation, biology, business.industry, Stem Cells, Recovery of Function, General Medicine, Antineoplastic Agents, Phytogenic, Intestinal epithelium, Gastrointestinal Tract, Wnt Proteins, Transplantation, Nitric oxide synthase, Bromodeoxyuridine, Immunology, Toxicity, biology.protein, Camptothecin, Tumor necrosis factor alpha, Stem cell, business, DNA Damage, Drugs, Chinese Herbal, Signal Transduction |
| الوصف: | PHY906, a four-herb Chinese medicine formula first described 1800 years ago, decreases gastrointestinal toxicity induced by the chemotherapeutic drug CPT-11 (irinotecan), as shown in a phase I/II clinical study. Similarly, in a murine colon 38 allograft model, PHY906 increased the antitumor activity of CPT-11 while decreasing animal weight loss caused by CPT-11. Here, we have further examined the effect of PHY906 on the intestinal toxicity caused by CPT-11 in mice. PHY906 did not protect against the initial DNA damage and apoptosis triggered by CPT-11 in the intestine, but by 4 days after CPT-11 treatment, PHY906 had restored the intestinal epithelium by promoting the regeneration of intestinal progenitor or stem cells and several Wnt signaling components. PHY906 also potentiated Wnt3a activity in human embryonic kidney-293 cells. Furthermore, PHY906 exhibited anti-inflammatory effects in mice by decreasing the infiltration of neutrophils or macrophages, tumor necrosis factor-alpha expression in the intestine, and proinflammatory cytokine concentrations in plasma. Chemical constituents of PHY906 potently inhibited nuclear factor kappaB, cyclooxygenase-2, and inducible nitric oxide synthase. Our results show that the herbal medicine PHY906 can counteract the toxicity of CPT-11 via several mechanisms that act simultaneously. |
| تدمد: | 1946-6242 1946-6234 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b7046276a2e50d557129b9ca4e9101 https://doi.org/10.1126/scitranslmed.3001270 |
| رقم الأكسشن: | edsair.doi.dedup.....31b7046276a2e50d557129b9ca4e9101 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19466242 19466234 |
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