Cytological Scoring and Prognosis of Poorly Differentiated Endometrioid Adenocarcinoma
| العنوان: | Cytological Scoring and Prognosis of Poorly Differentiated Endometrioid Adenocarcinoma |
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| المؤلفون: | Ichio Fukasawa, Yasuhiro Udagawa, Yutaka Hirasawa, Kiyoshi Hasegawa, Yutaka Torii, Rina Kato |
| المصدر: | Acta Cytologica. 59:83-90 |
| بيانات النشر: | S. Karger AG, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Oncology, medicine.medical_specialty, Histology, Biopsy, Pathology and Forensic Medicine, Endometrium, Internal medicine, medicine, Humans, Endometrioid adenocarcinoma, Aged, Aged, 80 and over, Cell Nucleus, business.industry, Poorly differentiated, Cell Differentiation, General Medicine, Middle Aged, Prognosis, Survival Analysis, Chromatin, Endometrial Neoplasms, Endometrial cytology, Clinicopathological features, Female, business, Carcinoma, Endometrioid |
| الوصف: | Objective: Histopathological variation has been demonstrated in grade 3 endometrioid adenocarcinomas. We attempted to evaluate the clinicopathological features of grade 3 tumors by endometrial cytological features using a scoring system. Study Design: Twenty-one endometrial cytological samples were evaluated using 5 cytological features: rates of cluster formation in tumor cells; nuclear pleomorphism; nuclear dimension; size of nucleoli, and chromatin structure and distribution. The relationships between cytological scores and clinicopathological factors or prognosis were investigated. Results: The median cytological score was 6 (range 4-14); therefore, samples with scores of 4-5 were defined as having low scores, while those with scores of 6-14 were defined as high scores. The accuracy of the cytological diagnosis for grade 3 tumors in the high score group (8/10 patients, 80.0%) was significantly higher than that of the low score group (2/11 patients, 18.2%; p = 0.009). Significant relationships between cytological scores and lymph node metastases or positive peritoneal cytology were observed (p = 0.03 and 0.035, respectively). The overall survival rate was significantly worse in the high score group (30.0%) than the low score group (88.9%; p = 0.02). Conclusions: Grade 3 endometrioid adenocarcinomas varied in cytological features; according to the scoring system used, high scores were associated with worse clinicopathological factors and poorer prognosis than low scores. |
| تدمد: | 1938-2650 0001-5547 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324a8a6eb1a2cd94ad16764952cd3b64 https://doi.org/10.1159/000375113 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....324a8a6eb1a2cd94ad16764952cd3b64 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19382650 00015547 |
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