Response to neoadjuvant chemotherapy and survival in molecular subtypes of resectable gastric cancer: a post hoc analysis of the D1/D2 and CRITICS trials

التفاصيل البيبلوغرافية
العنوان: Response to neoadjuvant chemotherapy and survival in molecular subtypes of resectable gastric cancer: a post hoc analysis of the D1/D2 and CRITICS trials
المؤلفون: Hedde D. Biesma, Tanya T. D. Soeratram, Karolina Sikorska, Irene A. Caspers, Hendrik F. van Essen, Jacqueline M. P. Egthuijsen, Aart Mookhoek, Hanneke W. M. van Laarhoven, Mark I. van Berge Henegouwen, Marianne Nordsmark, Donald L. van der Peet, Fabienne A. R. M. Warmerdam, Maud M. Geenen, Olaf J. L. Loosveld, Johanneke E. A. Portielje, Maartje Los, Daniëlle A. M. Heideman, Elma Meershoek-Klein Kranenbarg, Henk H. Hartgrink, Johanna van Sandick, Marcel Verheij, Cornelis J. H. van de Velde, Annemieke Cats, Bauke Ylstra, Nicole C. T. van Grieken
المساهمون: Pathology, Internal medicine, Surgery, CCA - Cancer Treatment and quality of life, Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Cancer biology and immunology, Radiation Oncology
المصدر: Gastric Cancer, 25, 3, pp. 640-651
Biesma, H D, Soeratram, T T D, Sikorska, K, Caspers, I A, van Essen, H F, Egthuijsen, J M P, Mookhoek, A, van Laarhoven, H W M, van Berge Henegouwen, M I, Nordsmark, M, van der Peet, D L, Warmerdam, F A R M, Geenen, M M, Loosveld, O J L, Portielje, J E A, Los, M, Heideman, D A M, Meershoek-Klein Kranenbarg, E, Hartgrink, H H, van Sandick, J, Verheij, M, van de Velde, C J H, Cats, A, Ylstra, B & van Grieken, N C T 2022, ' Response to neoadjuvant chemotherapy and survival in molecular subtypes of resectable gastric cancer : a post hoc analysis of the D1/D2 and CRITICS trials ', Gastric Cancer, vol. 25, no. 3, pp. 640-651 . https://doi.org/10.1007/s10120-022-01280-2
Gastric Cancer, 25(3), 640-651. Springer Japan
Gastric Cancer, 25, 640-651. SPRINGER
Gastric Cancer, 25, 640-651
بيانات النشر: Springer Science and Business Media LLC, 2022.
سنة النشر: 2022
مصطلحات موضوعية: Clinical Trials as Topic, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Cancer Research, Stomach neoplasms, Histopathological response, Gastroenterology, General Medicine, Prognosis, Neoadjuvant Therapy, digestive system diseases, Epstein-Barr virus (EBV), Epstein–Barr virus (EBV), Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Oncology, Humans, Microsatellite Instability, Mucinous differentiation, Microsatellite instability (MSI)
الوصف: Background Epstein–Barr virus positivity (EBV+) and microsatellite instability (MSI-high) are positive prognostic factors for survival in resectable gastric cancer (GC). However, benefit of perioperative treatment in patients with MSI-high tumors remains topic of discussion. Here, we present the clinicopathological outcomes of patients with EBV+, MSI-high, and EBV−/MSS GCs who received either surgery only or perioperative treatment. Methods EBV and MSI status were determined on tumor samples collected from 447 patients treated with surgery only in the D1/D2 trial, and from 451 patients treated perioperatively in the CRITICS trial. Results were correlated to histopathological response, morphological tumor characteristics, and survival. Results In the D1/D2 trial, 5-year cancer-related survival was 65.2% in 47 patients with EBV+, 56.7% in 47 patients with MSI-high, and 47.6% in 353 patients with EBV−/MSS tumors. In the CRITICS trial, 5-year cancer-related survival was 69.8% in 25 patients with EBV+, 51.7% in 27 patients with MSI-high, and 38.6% in 402 patients with EBV−/MSS tumors. Interestingly, all three MSI-high tumors with moderate to complete histopathological response (3/27, 11.1%) had substantial mucinous differentiation. No EBV+ tumors had a mucinous phenotype. 115/402 (28.6%) of EBV−/MSS tumors had moderate to complete histopathological response, of which 23/115 (20.0%) had a mucinous phenotype. Conclusions In resectable GC, MSI-high had favorable outcome compared to EBV−/MSS, both in patients treated with surgery only, and in those treated with perioperative chemo(radio)therapy. Substantial histopathological response was restricted to mucinous MSI-high tumors. The mucinous phenotype might be a relevant parameter in future clinical trials for MSI-high patients.
وصف الملف: application/pdf
تدمد: 1436-3305
1436-3291
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324d603ba1cdd3ed2ad3cf2ff0c5d83a
https://doi.org/10.1007/s10120-022-01280-2
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....324d603ba1cdd3ed2ad3cf2ff0c5d83a
قاعدة البيانات: OpenAIRE