Role of HCV Viremia in Corroborated HCV Transmission Events Within Young Adult Injecting Partnerships
| العنوان: | Role of HCV Viremia in Corroborated HCV Transmission Events Within Young Adult Injecting Partnerships |
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| المؤلفون: | David J. Bean, Jennifer L. Evans, Judith A. Hahn, Meghan D. Morris, Kimberly Page, Todd M. Allen, Damien C. Tully, Alya Briceno |
| المصدر: | Open forum infectious diseases, vol 6, iss 4 Open Forum Infectious Diseases |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | hepatitis C virus, 0301 basic medicine, medicine.medical_specialty, Hepatitis C virus, Chronic Liver Disease and Cirrhosis, 030106 microbiology, Viremia, medicine.disease_cause, Major Articles, Hepatitis, 03 medical and health sciences, 0302 clinical medicine, Hepatitis - C, Clinical Research, Internal medicine, phylogenetic linkage, Medicine, 030212 general & internal medicine, Young adult, Prospective cohort study, business.industry, Transmission (medicine), Liver Disease, Prevention, virus diseases, Odds ratio, Hepatitis C, medicine.disease, Confidence interval, 3. Good health, acute hepatitis C infection, Emerging Infectious Diseases, Good Health and Well Being, Infectious Diseases, Oncology, HIV/AIDS, Digestive Diseases, Infection, injecting partnerships, business |
| الوصف: | Author(s): Hahn, Judith A; Tully, Damien C; Evans, Jennifer L; Morris, Meghan D; Briceno, Alya; Bean, David J; Allen, Todd M; Page, Kimberly | Abstract: BackgroundHepatitis C virus (HCV), a major cause of morbidity and mortality, is common and rising among young persons who inject drugs (PWID). Reducing the level of viremia may be an intervention, yet the impact of viremia on HCV transmission is unknown.MethodsWe conducted a prospective study of injecting partnerships (Partner Study) of young adult (age l 30 years) PWID within the UFO Study, which enrolled those at risk for HCV or with seronegative viremic infection and up to 3 HCV RNA-positive regular injecting partners. We examined the level of HCV viremia and stage of infection in the HCV-positive partner in regression analyses of HCV transmission events that were corroborated via HCV phylogenetic linkage analyses.ResultsWe enrolled 69 at-risk/acutely infected PWID. There were 25 new HCV infections (incidence rate, 35.9 per 100 person-years; 95% confidence interval [CI], 24.3-53.2 per 100 person-years); 12/25 (48%) were phylogenetically linked to at least 1 partner. We found no association between the infected partner's quantitative level of HCV viremia and likely transmission in multivariate analyses (adjusted odds ratio [AOR], 0.90; 95% confidence interval [CI], 0.55-1.46); however, seronegative viremic infection in the infected partner was associated with increased transmission (AOR, 28.02; 95% CI, 5.61-139.95).ConclusionsThe HCV viremia level was not associated with increased odds of transmission, yet acute HCV infection (seronegative viremic) was. Explanations include high-risk behavior during acute infection or missed fluctuations in viremia during acute infection. Both point to the need for frequent testing to detect new infection and attempt to prevent onward transmission. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2328-8957 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32574b35786052d5feb9fc27eaeb692c https://researchonline.lshtm.ac.uk/id/eprint/4652880/1/ofz125(1).pdf |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....32574b35786052d5feb9fc27eaeb692c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23288957 |
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