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Analysis of sex hormone, menstruation and ovarian reserve in COVID-19 women of child-bearing age: a cross-sectional study

التفاصيل البيبلوغرافية
العنوان: Analysis of sex hormone, menstruation and ovarian reserve in COVID-19 women of child-bearing age: a cross-sectional study
المؤلفون: Kezhen Li, Qiuyue Liao, Hualin Bai, Shiyeow Lee, Cheng Wang, Huijun Li, Jihui Ai, Ge Chen, Jing Chen, Hongyan Hou, Liming Cheng
المصدر: Reproductive Biomedicine
Reproductive BioMedicine
بيانات النشر: Published by Elsevier Ltd on behalf of Reproductive Healthcare Ltd., 2020.
سنة النشر: 2020
مصطلحات موضوعية: 0301 basic medicine, Physiology, Comorbidity, Severity of Illness Index, Menstruation, 0302 clinical medicine, Sex hormone-binding globulin, Obstetrics and Gynaecology, Menstrual change, Young adult, Gonadal Steroid Hormones, Ovarian Reserve, media_common, 030219 obstetrics & reproductive medicine, biology, Reproduction, Age Factors, Obstetrics and Gynecology, Middle Aged, medicine.anatomical_structure, Female, Adult, China, Adolescent, media_common.quotation_subject, Ovary, Article, 03 medical and health sciences, Young Adult, Diabetes mellitus, medicine, Humans, Ovarian reserve, Menstrual cycle, Menstrual Cycle, Retrospective Studies, business.industry, SARS-CoV-2, COVID-19, medicine.disease, Ovarian function, 030104 developmental biology, Cross-Sectional Studies, Reproductive Medicine, biology.protein, business, Hormone, Developmental Biology
الوصف: Research question Does SARS-CoV-2 infection have an effect on ovarian reserve, sex hormones and menstruation of women of child-bearing age? Design This is a retrospective, cross-sectional study in which clinical and laboratory data from 237 women of child-bearing age diagnosed with COVID-19 were retrospectively reviewed. Menstrual data from 177 patients were analysed. Blood samples from the early follicular phase were tested for sex hormones and anti-Mullerian hormone (AMH). Results Among 237 patients with confirmed COVID-19, severely ill patients had more comorbidities than mildly ill patients (34% versus 8%), particularly for patients with diabetes, hepatic disease and malignant tumours. Of 177 patients with menstrual records, 45 (25%) patients presented with menstrual volume changes, and 50 (28%) patients had menstrual cycle changes, mainly a decreased volume (20%) and a prolonged cycle (19%). The average sex hormone and AMH concentrations of women of child-bearing age with COVID-19 were not different from those of age-matched controls. Conclusions Average sex hormone concentrations and ovarian reserve did not change significantly in COVID-19 women of child-bearing age. Nearly one-fifth of patients exhibited a menstrual volume decrease or cycle prolongation. The menstruation changes of these patients might be the consequence of transient sex hormone changes caused by suppression of ovarian function that quickly resume after recovery.
اللغة: English
تدمد: 1472-6491
1472-6483
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328166b97f8ab9946e92b46506d34133
http://europepmc.org/articles/PMC7522626
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....328166b97f8ab9946e92b46506d34133
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14726491
14726483