Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models
| العنوان: | Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models |
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| المؤلفون: | Kuldeep Singh, Natalia Malkova, Christian Hotz, Jan Diekmann, Gang Zheng, Sonja Witzel, Michelle Callahan, Qunyan Yu, Hui Qu, Joanne Lager, Dinesh S. Bangari, Serena Masciari, Gary J. Nabel, Julia Schlereth, Yu-an Zhang, Andreas Kuhn, Dmitri Wiederschain, Karl Hsu, Ugur Sahin, Marie Bernardo, Mustafa Diken, Mikhail Levit, Friederike Gieseke, Andy Hebert, Bodo Tillmann, Abderaouf Selmi, Jack Pollard, Sue Ryan, Christian Grunwitz, Fangxian Sun, Katalin Karikó, Lena Wicke, Hui Cao, William Weber, Timothy R. Wagenaar, Sebastian Kreiter, Tatiana Tolstykh |
| المصدر: | Cancer Cell |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Messenger RNA, Antitumor immunity, business.industry, medicine.medical_treatment, RNA, Neoplasms therapy, General Medicine, Immunotherapy, Article, Immune system, Neoplasms, Cancer research, Systemic administration, Cytokines, Humans, Medicine, RNA, Messenger, business, Gene |
| الوصف: | Local immunotherapy ideally stimulates immune responses against tumors while avoiding toxicities associated with systemic administration. Current strategies for tumor-targeted, gene-based delivery, however, are limited by adverse effects such as off-targeting or antivector immunity. We investigated the intratumoral administration of saline-formulated messenger (m)RNA encoding four cytokines that were identified as mediators of tumor regression across different tumor models: interleukin-12 (IL-12) single chain, interferon-α (IFN-α), granulocyte-macrophage colony-stimulating factor, and IL-15 sushi. Effective antitumor activity of these cytokines relied on multiple immune cell populations and was accompanied by intratumoral IFN-γ induction, systemic antigen-specific T cell expansion, increased granzyme B |
| تدمد: | 1946-6242 1946-6234 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ad00a44220c5d4522fd2289ce47795 https://doi.org/10.1126/scitranslmed.abc7804 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....32ad00a44220c5d4522fd2289ce47795 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19466242 19466234 |
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