Electrochemical profiling and liquid chromatography–mass spectrometry characterization of synthetic cathinones: From methodology to detection in forensic samples
| العنوان: | Electrochemical profiling and liquid chromatography–mass spectrometry characterization of synthetic cathinones: From methodology to detection in forensic samples |
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| المؤلفون: | Nick Sleegers, Alexander L.N. van Nuijs, Karolien De Wael, Jorrit van den Berg, Jonas Schram, Filip Van Durme, Marc Parrilla |
| المصدر: | Drug testing and analysis Drug Testing and Analysis |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Calibration curve, Methylone, Pharmaceutical Science, Mass spectrometry, 01 natural sciences, Gas Chromatography-Mass Spectrometry, Mass Spectrometry, Analytical Chemistry, 03 medical and health sciences, Alkaloids, 0302 clinical medicine, Mephedrone, Liquid chromatography–mass spectrometry, medicine, Environmental Chemistry, 030216 legal & forensic medicine, Butylone, Biology, Spectroscopy, Psychotropic Drugs, Chromatography, Illicit Drugs, Chemistry, Ethcathinone, Pharmacology. Therapy, 010401 analytical chemistry, Electrochemical Techniques, 0104 chemical sciences, Electrode, Oxidation-Reduction, Engineering sciences. Technology, Chromatography, Liquid, medicine.drug |
| الوصف: | The emergence of new psychoactive drugs in the market demands rapid and accurate tools for the on‐site classification of illegal and legal compounds with similar structures. Herein, a novel method for the classification of synthetic cathinones (SC) is presented based on their electrochemical profile. First, the electrochemical profile of five common SC (i.e., mephedrone, ethcathinone, methylone, butylone and 4‐chloro‐alpha‐pyrrolidinovalerophenone) is collected to build calibration curves using square wave voltammetry on graphite screen‐printed electrodes (SPE). Second, the elucidation of the oxidation pathways, obtained by liquid chromatography‐high resolution mass spectrometry, allows the pairing of the oxidation products to the SC electrochemical profile, providing a selective and robust classification. Additionally, the effect of common adulterants and illicit drugs on the electrochemical profile of the SC is explored. Interestingly, a cathodic pretreatment of the SPE allows the selective detection of each SC in presence of electroactive adulterants. Finally, the electrochemical approach is validated with gas‐chromatography‐mass spectrometry by analyzing 26 confiscated samples from seizures and illegal webshops. Overall, the electrochemical method exhibits a successful classification of SC including structural derivatives, a crucial attribute in an ever‐diversifying drug market. |
| تدمد: | 1942-7611 1942-7603 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c21cb34fe87ebf84f60b0511749976 https://doi.org/10.1002/dta.3018 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....32c21cb34fe87ebf84f60b0511749976 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19427611 19427603 |
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