Growth rate of coeliac children is compromised before the onset of the disease
| العنوان: | Growth rate of coeliac children is compromised before the onset of the disease |
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| المؤلفون: | Caroline Meijer, Judith Gyimesi, Sybille Koletzko, Riccardo Troncone, Donatella Cielo, Alfredo Chiurazzi, Renata Auricchio, Sanja Kolaček, Corina Hartman, Malgoscia Pieścik-Lech, Martina Galatola, Ilma Rita Korponay-Szabó, Hania Szajewska, Dario Bruzzese, Carmen Ribes-Koninckx, Gemma Castilljeo, M. L. Mearin, Raanan Shamir, Paula Crespo Escobar, Isabel Polanco, Pio Stellato, Luigi Greco |
| المساهمون: | Auricchio, Renata, Stellato, Pio, Bruzzese, Dario, Cielo, Donatella, Chiurazzi, Alfredo, Galatola, Martina, Castilljeo, Gemma, Crespo Escobar, Paula, Gyimesi, Judith, Hartman, Corina, Kolacek, Sanja, Koletzko, Sybille, Korponay-Szabo, Ilma, Mearin, Maria Luisa, Meijer, Caroline, Pieścik-Lech, Malgoscia, Polanco, Isabel, Ribes-Koninckx, Carmen, Shamir, Raanan, Szajewska, Hania, Troncone, Riccardo, Greco, Luigi |
| المصدر: | ARCHIVES OF DISEASE IN CHILDHOOD r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname Archives of Disease in Childhood, 105(10), 964-968. BMJ PUBLISHING GROUP |
| بيانات النشر: | BMJ Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Pediatrics, medicine.medical_specialty, growth, gastroenterology, Disease, Coeliac disease, Serology, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, medicine, Humans, Growth rate, Longitudinal Studies, Genetic risk, paediatric practice, Child, Growth Disorders, business.industry, Body Weight, Infant, Newborn, Infant, medicine.disease, Body Height, Celiac Disease, Case-Control Studies, Child, Preschool, Pediatrics, Perinatology and Child Health, 030211 gastroenterology & hepatology, Female, business, gastroenterology, growth, paediatric practice, Rate of growth |
| الوصف: | IntroductionGrowth impairment has often been described in children who develop coeliac disease (CD). Based on data from the multicentre, longitudinal PreventCD study, we analysed the growth patterns of infants at genetic risk of CD, comparing those who developed CD by 6 years of age (CD ‘cases’, 113 infants) versus those who did not develop CD by 6 years (no CD ‘controls’, 831 infants).MethodsWeight and length/height were measured using a longitudinal protocol. Raw measurements were standardised, computing z-scores for length/height and weight; a linear mixed model was fitted to the data in order to compare the rate of growth in the two cohorts.ResultsNeither cases nor controls had significant growth failure. However, when the mean z-scores for weight and height were analysed, there was a difference between the two groups starting at fourth month of life. When the growth pattern in the first year was analysed longitudinally using mixed models, it emerged that children who develop CD had a significantly lower growth rate in weight z-score (−0.028/month; 95% CI −0.038 to −0.017; pConclusionThe growth of children at risk of CD rarely fell below ‘clinical standards’. However, growth rate was significantly lower in cases than in controls. Our data suggest that peculiar pathways of growth are present in children who develop CD, long before any clinical or serological signs of the disease appear. |
| تدمد: | 0003-9888 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32db6147ee36151639b4f0c4ccbc796f https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=12557 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....32db6147ee36151639b4f0c4ccbc796f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00039888 |
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