التفاصيل البيبلوغرافية
| العنوان: |
Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models |
| المؤلفون: |
Anke Ryll, Steffen Klamt, Jens Niklas, Emanuel Gonçalves, Julio Saez-Rodriguez, Miguel Rocha, Klaus Mauch, Joachim Bucher |
| المصدر: |
Molecular BioSystems |
| سنة النشر: |
2013 |
| مصطلحات موضوعية: |
Regulation of gene expression, 0303 health sciences, Mathematical model, Cell behaviour, Nanotechnology, Computational biology, Biology, Medical research, Models, Biological, Bridging (programming), 03 medical and health sciences, 0302 clinical medicine, Signalling, Gene Expression Regulation, 030220 oncology & carcinogenesis, Signal transduction, Molecular Biology, Metabolic Networks and Pathways, 030304 developmental biology, Biotechnology, Signal Transduction |
| الوصف: |
Mathematical modelling is increasingly becoming an indispensable tool for the study of cellular processes, allowing their analysis in a systematic and comprehensive manner. In the vast majority of the cases, models focus on specific subsystems, and in particular describe either metabolism, gene expression or signal transduction. Integrated models that are able to span and interconnect these layers are, by contrast, rare as their construction and analysis face multiple challenges. Such methods, however, would represent extremely useful tools to understand cell behaviour, with application in distinct fields of biological and medical research. In particular, they could be useful tools to study genotype–phenotype mappings, and the way they are affected by specific conditions or perturbations. Here, we review existing computational approaches that integrate signalling, gene regulation and/or metabolism. We describe existing challenges, available methods and point at potentially useful strategies. © Royal Society of Chemistry 2013 [accessed 2013 September 9th] |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333583da8fd37b20a806221c5a531317
https://hdl.handle.net/11858/00-001M-0000-0014-4E44-711858/00-001M-0000-0014-4E40-F |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi.dedup.....333583da8fd37b20a806221c5a531317 |
| قاعدة البيانات: |
OpenAIRE |
