Myocardial Infarction and Atrial Fibrillation
| العنوان: | Myocardial Infarction and Atrial Fibrillation |
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| المؤلفون: | Walter P. Abhayaratna, Kurt C. Roberts-Thomson, Dennis H. Lau, Han S. Lim, Anthony G. Brooks, Pawel Kuklik, Matthew I. Worthley, David A. Saint, Muayad Alasady, Nicholas J. Shipp, D. Barlow, Prashanthan Sanders |
| المصدر: | Circulation: Arrhythmia and Electrophysiology. 6:738-745 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Acute coronary syndrome, medicine.medical_specialty, Time Factors, Myocardial ischemia, Refractory Period, Electrophysiological, Myocardial Infarction, Ischemia, Action Potentials, Ventricular Function, Left, Ventricular Dysfunction, Left, Atrial Pressure, Animal model, Heart Rate, Risk Factors, Physiology (medical), Internal medicine, Atrial Fibrillation, Animals, Medicine, Heart Atria, cardiovascular diseases, Myocardial infarction, Sheep, Ventricular function, business.industry, Atrial fibrillation, medicine.disease, Disease Models, Animal, cardiovascular system, Cardiology, Atrial Function, Left, Electrophysiologic Techniques, Cardiac, Cardiology and Cardiovascular Medicine, business, Heart atrium |
| الوصف: | Background— Myocardial infarction (MI) is associated with the development of atrial fibrillation (AF). We aimed to characterize the atrial abnormalities because of MI and determine the role of ischemia to the AF substrate. Methods and Results— Forty-four sheep were studied. MI was induced by occlusion of the left circumflex artery (LCX) or left anterior descending artery (LAD). Excluding 11 with fatal arrhythmias, equal groups of animals (LCX; LAD; and sham-operated) underwent sequential electrophysiology study for 45 minutes to determine atrial effective refractory periods, conduction velocity, conduction heterogeneity index, and AF inducibility. Postmortem evaluation was performed with 2,3,5 triphenyl tetrazolium chloride staining. MI resulted in greater left ventricular dysfunction ( P P P P P P P P P P P P Conclusions— Left ventricular infarction, which is known to result in atrial stretch, hemodynamic change, and neurohumoral activation, contributes partially to the atrial abnormalities in MI. Atrial ischemia/infarction results in greater atrial electrophysiological changes and propensity for AF forming the dominant substrate for AF in MI. |
| تدمد: | 1941-3084 1941-3149 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338ad6ba4ef94d882c36077dd4d3d8c2 https://doi.org/10.1161/circep.113.000163 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....338ad6ba4ef94d882c36077dd4d3d8c2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19413084 19413149 |
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