Gender differences in HIV-1 diversity at time of infection
| العنوان: | Gender differences in HIV-1 diversity at time of infection |
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| المؤلفون: | Harold L. Martin, Denis J. Jackson, Joel P. Rakwar, Joan K. Kreiss, Rainwater Sm, Long Em, Kishorchandra Mandaliya, Ludo Lavreys, Julie Overbaugh |
| المصدر: | Nature Medicine. 6:71-75 |
| بيانات النشر: | Springer Science and Business Media LLC, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Adult, Male, Molecular Sequence Data, Population, HIV Infections, Biology, Genes, env, General Biochemistry, Genetics and Molecular Biology, Virus, Cohort Studies, Sex Factors, Proviruses, HIV Seropositivity, Disease Transmission, Infectious, Humans, Amino Acid Sequence, Seroconversion, Heterosexuality, education, Index case, Phylogeny, Sex Characteristics, education.field_of_study, Transmission (medicine), Gene Products, env, Genetic Variation, General Medicine, Kenya, Virology, HIV-1, Female, Cohort study, Sex characteristics |
| الوصف: | To develop an HIV-1 vaccine with global efficacy, it is important to identify and characterize the viruses that are transmitted, particularly to individuals living in areas of high incidence. Several studies have shown that virus from the blood of acutely infected adults was homogeneous, even when the virus population in the index case was genetically diverse. In contrast to those results with mainly male cohorts in America and Europe, in several cases a heterogeneous virus population has been found early in infection in women in Africa. Thus, we more closely compared the diversity of transmitted HIV-1 in men and women who became infected through heterosexual contact. We found that women from Kenya were often infected by multiple virus variants, whereas men from Kenya were not. Moreover, a heterogeneous virus was present in the women before their seroconversion, and in each woman it was derived from a single index case, indicating that diversity was most likely to be the result of transmission of multiple variants. Our data indicate that there are important differences in the transmitted virus populations in women and men, even when cohorts from the same geographic region who are infected with the same subtypes of HIV-1 are compared. |
| تدمد: | 1546-170X 1078-8956 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33913a4d2dff53c0a300050fcd4253f5 https://doi.org/10.1038/71563 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....33913a4d2dff53c0a300050fcd4253f5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1546170X 10788956 |
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