التفاصيل البيبلوغرافية
العنوان:
A kinase-cGAS cascade to synthesize a therapeutic STING activator
المؤلفون:
John A. McIntosh , Zhijian Liu , Brian M. Andresen , Nastaran Salehi Marzijarani , Jeffrey C. Moore , Nicholas M. Marshall , Margie Borra-Garske , Jennifer V. Obligacion , Patrick S. Fier , Feng Peng , Jacob H. Forstater , Matthew S. Winston , Chihui An , Wonsuk Chang , Jongwon Lim , Mark A. Huffman , Steven P. Miller , Fuh-Rong Tsay , Michael D. Altman , Charles A. Lesburg , Dietrich Steinhuebel , B. Wesley Trotter , Jared N. Cumming , Alan Northrup , Xiaodong Bu , Benjamin F. Mann , Mirlinda Biba , Kaori Hiraga , Grant S. Murphy , Joshua N. Kolev , Amanda Makarewicz , Weilan Pan , Iman Farasat , Rachel S. Bade , Kevin Stone , Da Duan , Oscar Alvizo , Donovan Adpressa , Erik Guetschow , Erik Hoyt , Erik L. Regalado , Steve Castro , Nelo Rivera , Joseph P. Smith , Fengqiang Wang , Alejandro Crespo , Deeptak Verma , Stephanus Axnanda , Zachary E. X. Dance , Paul N. Devine , David Tschaen , Keith A. Canada , Paul G. Bulger , Benjamin D. Sherry , Matthew D. Truppo , Rebecca T. Ruck , Louis-Charles Campeau , David Jonathan Bennett , Guy R. Humphrey , Kevin R. Campos , Matthew L. Maddess
المصدر:
Nature . 603(7901)
سنة النشر:
2021
مصطلحات موضوعية:
Multidisciplinary , Adenosine , Guanosine , Animals , Membrane Proteins , Interferons , Nucleotidyltransferases , Signal Transduction
الوصف:
The introduction of molecular complexity in an atom- and step-efficient manner remains an outstanding goal in modern synthetic chemistry. Artificial biosynthetic pathways are uniquely able to address this challenge by using enzymes to carry out multiple synthetic steps simultaneously or in a one-pot sequence
تدمد:
1476-4687
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a99659551d71437d1bb960c572370b https://pubmed.ncbi.nlm.nih.gov/35296845
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....33a99659551d71437d1bb960c572370b
قاعدة البيانات:
OpenAIRE
Find this article in full text from Springer Verlag. 