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Atrial function in Fontan patients assessed by CMR: Relation with exercise capacity and long-term outcomes

التفاصيل البيبلوغرافية
العنوان: Atrial function in Fontan patients assessed by CMR: Relation with exercise capacity and long-term outcomes
المؤلفون: Jelle P.G. van der Ven, Livia Kapusta, Saeed Juggan, Sjoerd S. M. Bossers, Rahul H. Rathod, Gabriëlle G. van Iperen, Irene M. Kuipers, Tarek Alsaied, Eva van den Bosch, Willem A. Helbing, Arend D. J. ten Harkel, Lucia J.M. Kroft
المساهمون: Pediatrics, Radiology & Nuclear Medicine, Paediatric Cardiology, AGEM - Inborn errors of metabolism, APH - Methodology, APH - Quality of Care
المصدر: International Journal of Cardiology, 312, 56-61. Elsevier Ireland Ltd
International journal of cardiology, 312, 56-61. Elsevier Ireland Ltd
International Journal of Cardiology, 312, 56-61
International Journal of Cardiology, 312, pp. 56-61
International Journal of Cardiology, 312, 56-61. ELSEVIER IRELAND LTD
سنة النشر: 2020
مصطلحات موضوعية: Heart Defects, Congenital, medicine.medical_specialty, Univentricular heart disease, Reservoir function, Heart Ventricles, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Extracardiac conduit, Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0], 030204 cardiovascular system & hematology, Fontan Procedure, Pediatrics, 03 medical and health sciences, 0302 clinical medicine, Cardiac magnetic resonance imaging, Internal medicine, Long term outcomes, medicine, Humans, 030212 general & internal medicine, cardiovascular diseases, Atrium (heart), CMR, Child, Exercise Tolerance, medicine.diagnostic_test, business.industry, Atrial function, VO2 max, Exercise capacity, medicine.anatomical_structure, Ventricle, Cardiology, cardiovascular system, Feature tracking strain, Cardiology and Cardiovascular Medicine, business, Fontan
الوصف: Objective: To assess the role of atrial function on exercise capacity and clinical events in Fontan patients.Design: We included 96 Fontan patients from6 tertiary centers, aged 12.8 (IQR 10.1-15.6) years, who underwent cardiacmagnetic resonance imaging and cardiopulmonary exercise testing within 12 months of each other from 2004 to 2017. Intra-atrial lateral tunnel (ILT) and extracardiac conduit (ECC) patients were matched 1:1 with regard to age, gender and dominant ventricle. The pulmonary venous atrium was manually segmented in all phases and slices. Atrial function was assessed by volume-time curves. Furthermore, atrial longitudinal and circumferential feature tracking strain was assessed. We determined the relation between atrial function and exercise capacity, assessed by peak oxygen uptake and VE/VCO2 slope, and events (mortality, listing for transplant, re-intervention, arrhythmia) during follow-up.Results: Atrial maximal and minimal volumes did not differ between ILT and ECC patients. ECC patients had higher reservoir function (21.1 [16.4-28.0]% vs 18.2 [10.9-22.2]%, p =.03), lower conduit function and lower total circumferential strain (13.8 +/- 5.1% vs 18.0 +/- 8.7%, p =.01), compared to ILT patients. Only for ECC patients, a better late peak circumferential strain rate predicted better VE/VCO2 slope. No other parameter of atrial function predicted peak oxygen uptake or VE/VCO2 slope. During a median follow-up of 6.2 years, 42 patients reached the composite end-point. No atrial function parameters predicted events during follow-up.Conclusions: ECC patients have higher atrial reservoir function and lower conduit function. Atrial function did not predict exercise capacity or events during follow-up. (c) 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
وصف الملف: application/pdf
اللغة: English
تدمد: 0167-5273
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b19683b24f11df85af76835952d9ad
https://pure.eur.nl/en/publications/07a39500-630f-4099-bffa-b74a8751647c
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....33b19683b24f11df85af76835952d9ad
قاعدة البيانات: OpenAIRE
الوصف
تدمد:01675273