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Urinary HPV DNA testing as a tool for cervical cancer screening in women who are reluctant to have a Pap smear in France

التفاصيل البيبلوغرافية
العنوان: Urinary HPV DNA testing as a tool for cervical cancer screening in women who are reluctant to have a Pap smear in France
المؤلفون: Pascal Veillon, Anne-Sophie Le Duc-Banaszuk, Alexandra Ducancelle, Adeline Pivert, Hélène Le Guillou-Guillemette, Caroline Lefeuvre, Françoise Lunel-Fabiani
المساهمون: Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Centre régional de coordination des dépistages des cancers-Pays de la Loire
المصدر: Journal of Infection
Journal of Infection, WB Saunders, 2020, 81 (2), pp.248-254. ⟨10.1016/j.jinf.2020.05.006⟩
بيانات النشر: HAL CCSD, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Adult, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Urinary system, [SDV]Life Sciences [q-bio], 030106 microbiology, Uterine Cervical Neoplasms, Urine, Cervical cancer screening, Sensitivity and Specificity, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Genotype, Biopsy, medicine, Humans, 030212 general & internal medicine, Papillomaviridae, Early Detection of Cancer, ComputingMilieux_MISCELLANEOUS, Aged, Medical attention, Vaginal Smears, Colposcopy, medicine.diagnostic_test, Obstetrics, business.industry, Papillomavirus Infections, virus diseases, Middle Aged, female genital diseases and pregnancy complications, 3. Good health, Hpv testing, Infectious Diseases, DNA, Viral, Female, France, business, Papanicolaou Test
الوصف: Summary Objectives In France, cervical cancer screening is based on human papillomavirus (HPV) testing on cervical samples (women aged 30-65) and cytological examination of Pap smears (25-29), but screening coverage is unsatisfactory. The CapU3 study aimed to propose urinary HPV testing on 13,535 women aged 35 to 65 who had not had a Pap smear since 2010. Methods High-risk HPV (HR-HPV) detection was performed using a real-time PCR (Anyplex II HPV 28 Detection, Seegene®). Women with HR-HPV positive results were encouraged to have a cervical smear as soon as possible to detect the presence of cervical lesions. Results The participation rate was 15.4%. Out of the 1,915 analyzed specimens, 1,711 and 190 were negative and positive, respectively, for at least 1 HR-HPV genotype. HR-HPV genotypes other than HPV-16 or HPV-18 were mostly detected as HPV-53 (23.7%) and HPV-68 (14.2%). A satisfactory gynecological follow-up was observed for HPV-positive women (92.1%). 23 abnormal smears were observed and eight high-grade cytological lesions after colposcopy and biopsy were diagnosed. Conclusions As home HPV urinary testing is non-invasive and does not require medical attention, this method may be an alternative for women who are reluctant to have a Pap smear and thus extend screening coverage.
اللغة: English
تدمد: 0163-4453
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e2d2832771256c0a9cbe446c718f8e
https://hal.univ-angers.fr/hal-03287281
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....33e2d2832771256c0a9cbe446c718f8e
قاعدة البيانات: OpenAIRE
الوصف
تدمد:01634453