Brain metastases from cervical cancer reduce longevity independent of overall tumor burden
| العنوان: | Brain metastases from cervical cancer reduce longevity independent of overall tumor burden |
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| المؤلفون: | Ariel Takayanagi, Pouria Yazdian, Syed A. Quadri, Omid R. Hariri, Andrew Sumida, Omid S. Tehrani, Joshua Cohen, T. J. Florence, Abigail A Armstrong |
| المصدر: | Surgical Neurology International |
| بيانات النشر: | Scientific Scholar, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Survival, Non-isolated, Metastases, Cervix, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Disseminated disease, Cancer, Isolated, Cervical cancer, business.industry, Uterus, Brain, Isolated brain, medicine.disease, Uterine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Surgery, Original Article, Cervical, Neurology (clinical), Neurosurgery, business, 030217 neurology & neurosurgery, Brain metastasis |
| الوصف: | Background: Isolated brain metastasis (IBM) from cervical cancer is a very rare encounter in neurosurgery. We sought to understand how patients with isolated brain metastases differ from those with metastases in the setting of widespread disease. Methods: A systematic review was completed using PubMed and the Cochrane Library. Patients with isolated brain metastases (IBM) and non-isolated brain metastases (NIBM, or brain metastases in the setting of disseminated disease), were compared. Two-sided statistical tests were used to determine significance. Survival function was carried out using the Kaplan–Meier method. Results: A total of 89 patients, 25 with IBM and 64 with NIBM, were identified. The time interval between initial diagnosis of cervical cancer and diagnosis of brain lesion was significantly shorter in the IBM group (median 7.5 vs. 20.05 months, and IBM vs. NIBM, respectively; P = 0.006). Overall survival from initial diagnosis of cervical cancer was significantly shorter for the IBM group versus the NIBM group (7.63 vs. 26.3 months, respectively; P = 0.0005). Data demonstrate a 3.4-fold reduction of median life expectancy to 7.63 months. Survival after diagnosis of brain metastases did not differ between groups (median, IBM 7 months vs. NIBM 4 months, P = 0.08). Conclusion: Taken together, our data suggest that for cervical cancer patients with brain metastasis intracranial metastasis itself (and not overall tumor burden) represent a sentinel event in limiting longevity. While the present study is underpowered to compare treatment options directly, further work should be focused on determining the optimal treatment for these patients. |
| اللغة: | English |
| تدمد: | 2152-7806 2229-5097 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3405e70de3485b686bf89204742cf8f8 http://europepmc.org/articles/PMC6763668 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3405e70de3485b686bf89204742cf8f8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21527806 22295097 |
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