A role for the melanocortin 4 receptor in sexual function
العنوان: | A role for the melanocortin 4 receptor in sexual function |
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المؤلفون: | Christopher P. Austin, Doreen E. Cashen, Sheng-Shung Pong, Brian D. Spar, Brett Connolly, Tung Ming Fong, D. Euan MacIntyre, Carina P. Tan, Michael R. Tota, Ravi P. Nargund, R. S. L. Chang, Oksana C. Palyha, Constantin Tamvakopoulos, Deborah L. Drazen, Anthony G. DiLella, Jennifer E. Drisko, David J. Figueroa, Tanya MacNeil, Andreas W. Sailer, David H. Weinberg, Randy J. Nelson, Charles Rosenblum, Cathy R.-R.C. Huang, Rui Tang, Arthur A. Patchett, Xiao-Ming Guan, Hong Yu, George J. Christ, Andrew D. Howard, Lex H.T. Van der Ploeg, William J. Martin, Aurawan Vongs, Iyassu K. Sebhat, Ralph A. Stearns |
المصدر: | Proceedings of the National Academy of Sciences. 99:11381-11386 |
بيانات النشر: | Proceedings of the National Academy of Sciences, 2002. |
سنة النشر: | 2002 |
مصطلحات موضوعية: | Male, Agonist, medicine.medical_specialty, DNA, Complementary, Intracranial Pressure, medicine.drug_class, Blood Pressure, In Vitro Techniques, Biology, Somatosensory system, Mice, Sexual Behavior, Animal, Nerve Fibers, Internal medicine, Copulation, medicine, Animals, Glans, In Situ Hybridization, DNA Primers, Multidisciplinary, Reverse Transcriptase Polymerase Chain Reaction, Human penis, Feeding Behavior, Ribonuclease, Pancreatic, Biological Sciences, Spinal cord, Electric Stimulation, Mice, Inbred C57BL, Melanocortin 4 receptor, medicine.anatomical_structure, Endocrinology, Receptors, Corticotropin, Models, Animal, Receptor, Melanocortin, Type 4, Brainstem, Energy Metabolism, Penis |
الوصف: | By using a combination of genetic, pharmacological, and anatomical approaches, we show that the melanocortin 4 receptor (MC4R), implicated in the control of food intake and energy expenditure, also modulates erectile function and sexual behavior. Evidence supporting this notion is based on several findings: ( i ) a highly selective non-peptide MC4R agonist augments erectile activity initiated by electrical stimulation of the cavernous nerve in wild-type but not Mc4r -null mice; ( ii ) copulatory behavior is enhanced by administration of a selective MC4R agonist and is diminished in mice lacking Mc4r; ( iii ) reverse transcription (RT)-PCR and non-PCR based methods demonstrate MC4R expression in rat and human penis, and rat spinal cord, hypothalamus, brainstem, pelvic ganglion (major autonomic relay center to the penis), but not in rat primary corpus smooth muscle cavernosum cells; and ( iv ) in situ hybridization of glans tissue from the human and rat penis reveal MC4R expression in nerve fibers and mechanoreceptors in the glans of the penis. Collectively, these data implicate the MC4R in the modulation of penile erectile function and provide evidence that MC4R-mediated proerectile responses may be activated through neuronal circuitry in spinal cord erectile centers and somatosensory afferent nerve terminals of the penis. Our results provide a basis for the existence of MC4R-controlled neuronal pathways that control sexual function. |
تدمد: | 1091-6490 0027-8424 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341db11f0e12a0307d07e04176cd4aad https://doi.org/10.1073/pnas.172378699 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....341db11f0e12a0307d07e04176cd4aad |
قاعدة البيانات: | OpenAIRE |
تدمد: | 10916490 00278424 |
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