Enhanced Sensing Behavior of Three-Dimensional Microfluidic Paper-Based Analytical Devices (3D-μPADs) with Evaporation-Free Enclosed Channels for Point-of-Care Testing
| العنوان: | Enhanced Sensing Behavior of Three-Dimensional Microfluidic Paper-Based Analytical Devices (3D-μPADs) with Evaporation-Free Enclosed Channels for Point-of-Care Testing |
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| المؤلفون: | Sungsu Park, Jaehyung Jeon, Dinesh Veeran Ponnuvelu, Chanyong Park |
| المصدر: | Diagnostics, Vol 11, Iss 977, p 977 (2021) Diagnostics Volume 11 Issue 6 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Medicine (General), Fabrication, Materials science, Clinical Biochemistry, Microfluidics, Flow (psychology), Evaporation, 3D printing, 02 engineering and technology, paper-based analytical devices, 01 natural sciences, Article, evaporation, R5-920, enclosed channel, business.industry, 010401 analytical chemistry, Paper based, 021001 nanoscience & nanotechnology, 0104 chemical sciences, point-of-care testing, Optoelectronics, small-volume sample, 0210 nano-technology, business, Sensitivity (electronics), Intensity (heat transfer) |
| الوصف: | Despite the potential in fabrication of microfluidic paper-based analytical devices (μPADs) for point-of-care testing (POCT) kits, the development of simple, accurate, and rapid devices with higher sensitivity remains challenging. Here, we report a novel method for 3D-μPAD fabrication with enclosed channels using vat photopolymerization to avoid fluid evaporation. In detail, height of the enclosed channels was adjusted from 0.3 to 0.17 mm by varying the UV exposure time from 1 to 4 s for the top barrier, whereas the exposure time for the bottom and side barriers was fixed. As a result, sample flow in the enclosed channels of 3D-μPADs showed lesser wicking speed with very scant evaporation compared to that in the hemi channels in the 3D-μPADs. The stoppage of evaporation in the enclosed channels significantly improved the gray intensity and uniformity in the detection zone of the 3D-μPADs, resulting in as low as 0.3 mM glucose detection. Thus 3D-μPADs with enclosed channels showed enhanced sensitivity compared to the 3D-μPADs with hemi channels when dealing with a small volume sample. Our work provides a new insight into 3D-μPAD design with enclosed channels, which redefines the methodology in 3D printing. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2075-4418 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342ed12a9d798f0fb2f087b9c7a8b9ff https://www.mdpi.com/2075-4418/11/6/977 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....342ed12a9d798f0fb2f087b9c7a8b9ff |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20754418 |
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