Neurological manifestations and neuro‐invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2
| العنوان: | Neurological manifestations and neuro‐invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2 |
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| المؤلفون: | Robrecht Raedt, Dimitri Hemelsoet, I. Garrez, Guy Laureys, Kristl Vonck, V. De Herdt, Paul Boon |
| المصدر: | European Journal of Neurology EUROPEAN JOURNAL OF NEUROLOGY |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Pediatrics, Neurological injury, Neurology, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Clinical Neurology, Disease, 03 medical and health sciences, 0302 clinical medicine, CEREBROSPINAL-FLUID, INFECTION, Medicine and Health Sciences, medicine, In patient, 030212 general & internal medicine, SARS-CoV-2, business.industry, COVID-19, Impaired consciousness, neuro-invasive mechanism, neurological manifestations, VIRUS, Neurology (clinical), Severe acute respiratory syndrome coronavirus, business, cerebrovascular diseases, 030217 neurology & neurosurgery |
| الوصف: | Background and purpose Infections with coronaviruses are not always confined to the respiratory tract and various neurological manifestations have been reported. The aim of this study was to perform a review to describe neurological manifestations in patients with COVID-19 and possible neuro-invasive mechanisms of Sars-CoV-2. Methods PubMed, Web of Science and COVID-dedicated databases were searched for the combination of COVID-19 terminology and neurology terminology up to 10 May 2020. Social media channels were followed up between 15 March and 10 May 2020 for postings with the same scope. Neurological manifestations were extracted from the identified papers and combined to provide a useful summary for the neurologist in clinical practice. Results Neurological manifestations potentially related to COVID-19 have been reported in large studies, case series and case reports and include acute cerebrovascular diseases, impaired consciousness, cranial nerve manifestations and autoimmune disorders such as the Guillain-Barre syndrome often present in patients with more severe COVID-19. Cranial nerve symptoms such as olfactory and gustatory dysfunctions are highly prevalent in patients with mild to moderate COVID-19 even without associated nasal symptoms and often present in an early stage of the disease. Conclusion Physicians should be aware of the neurological manifestations in patients with COVID-19, especially when rapid clinical deterioration occurs. The neurological symptoms in COVID-19 patients may be due to direct viral neurological injury or indirect neuroinflammatory and autoimmune mechanisms. No antiviral treatments against the virus or vaccines for its prevention are available and the long-term consequences of the infection on human health remain uncertain especially with regard to the neurological system. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1468-1331 1351-5101 |
| DOI: | 10.1111/ene.14329 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346491363fbb13280047df39bb9b312c |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....346491363fbb13280047df39bb9b312c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14681331 13515101 |
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| DOI: | 10.1111/ene.14329 |