Phylloid Hypermelanosis and Melanocytic Nevi with Aggregated and Disfigured Melanosomes: Causal Relationship between Phylloid Pigment Distribution and Chromosome 13 Abnormalities
| العنوان: | Phylloid Hypermelanosis and Melanocytic Nevi with Aggregated and Disfigured Melanosomes: Causal Relationship between Phylloid Pigment Distribution and Chromosome 13 Abnormalities |
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| المؤلفون: | Hiroshi Ikegami, Tomohiko Narita, Hiromi Kobayashi, Haruyo Sayasa, Akira Kawada, Naoki Oiso, Hisayoshi Imanishi, Daisuke Tsuruta |
| المصدر: | Dermatology. 220:169-172 |
| بيانات النشر: | S. Karger AG, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, Skin Neoplasms, Dermatology, Biology, Hyperpigmentation, Chromosomal Abnormality, medicine, Humans, Pigmentation disorder, Chromosome 13, Melanosome, Chromosome Aberrations, Melanins, Nevus, Pigmented, Melanosomes, Chromosomes, Human, Pair 13, Mosaicism, Melanocytic nevus, medicine.disease, Phylloid hypomelanosis, medicine.symptom |
| الوصف: | The mosaic pattern of phylloid hypomelanosis is mostly associated with chromosome 13 abnormalities. Recently, 1 case of hypermelanosis in a phylloid pattern has been described. We describe a 29-year-old Japanese male with mental retardation, phylloid hypermelanosis and histopathologically and ultrastructurally peculiar melanocytic nevi, which were associated with 3 aberrant chromosome 13 cell lines. The karyotyping of 30 peripheral blood lymphocytes showed 46,XY,r(13)(p11.2q34) in 21 cells, 45,XY,–13 in 7 cells and 46,XY,dic r(13)(p11.2q34) in 2 cells. Immunohistochemical staining with HMB45 showed a positive reaction to basal keratinocytes in phylloid hypermelanosis. HMB45 staining reacted to the nevus cells and keratinocytes in the melanocytic nevi. Electron microscopy of a specimen excised from a melanocytic nevus showed an unusual finding of aggregated and disfigured melanosomes in the keratinocytes. This case suggests that chromosome 13 abnormalities may be related to the development of phylloid hypermelanosis and the bizarre melanosomes in the keratinocytes of melanocytic nevi. |
| تدمد: | 1421-9832 1018-8665 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3493a54e5a5e077720f1af987e8b6234 https://doi.org/10.1159/000277273 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....3493a54e5a5e077720f1af987e8b6234 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219832 10188665 |
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