Abnormal bowel movement frequency increases the risk of rectal cancer: evidence from cohort studies with one million people
العنوان: | Abnormal bowel movement frequency increases the risk of rectal cancer: evidence from cohort studies with one million people |
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المؤلفون: | Chao Li, Liangfang Shen, Lin Shen, Zhanzhan Li, Na Li |
المصدر: | Bioscience Reports |
بيانات النشر: | Portland Press Ltd., 2020. |
سنة النشر: | 2020 |
مصطلحات موضوعية: | medicine.medical_specialty, Colorectal cancer, Biophysics, colorectal cancer, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Prevalence, cohort study, medicine, Humans, Prospective Studies, Defecation, Molecular Biology, Diagnostics & Biomarkers, Research Articles, Retrospective Studies, Cancer, Rectal Neoplasms, business.industry, Cell Biology, Publication bias, medicine.disease, Confidence interval, meta-analysis, bowel movement, 030220 oncology & carcinogenesis, Relative risk, Meta-analysis, Cohort, 030211 gastroenterology & hepatology, business, Follow-Up Studies, Cohort study |
الوصف: | Previous studies from case–control studies failed to draw reliable conclusions regarding the relationship between bowel movement frequency and the risk of colorectal cancer. To further examine this relationship, we collect the data from cohort studies that make a more accurate estimation. Several online data were searched from inception to February 29, 2020. Ten cohort studies involving 1,038,598 individuals were included in our study. The pooled results indicated that a bowel movement of less than once per day was not associated with the risk of colorectal cancer (relative risk (RR)= 1.00, 95% confidence interval (CI): 0.87–1.16, P = 0.950) compared with that of once per day. Compared with a bowel movement frequency of once per day, a bowel movement of more than once per day was also not related to elevated risk of colorectal cancer (RR = 1.04, 95% CI: 0.91–1.19, P = 0.570). The subgroup analyses indicated a low or high bowel movement frequency did not increase the risk of colon cancer (RR = 0.91, 95% CI: 0.80–1.03, P = 0.130). However, an increased frequency of bowel movements increased the risk of rectal cancer (RR = 1.34, 95% CI: 1.19–1.52, P < 0.001). The sensitivity analysis still supports the results. No significant publication bias existed. The data from cohort indicated that less bowel movement frequency was not associated with the risk of colorectal cancer. The frequency of bowel movement affects the risk of rectal cancer. |
تدمد: | 1573-4935 0144-8463 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a88f146f598ad82bfed623f3f479bc https://doi.org/10.1042/bsr20200355 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....34a88f146f598ad82bfed623f3f479bc |
قاعدة البيانات: | OpenAIRE |
تدمد: | 15734935 01448463 |
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