Structure of the human CRFB4 gene: comparison with its IFNAR neighbor
| العنوان: | Structure of the human CRFB4 gene: comparison with its IFNAR neighbor |
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| المؤلفون: | Melvin G. McInnis, Stylianos E. Antonarakis, Georges Lutfalla, G. Uze |
| المساهمون: | Dynamique des interactions membranaires normales et pathologiques (DIMNP), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Montpellier 1 (UM1), Défenses antivirales et antitumorales (DAA), Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Journal of Molecular Evolution Journal of Molecular Evolution, Springer Verlag, 1995, 41 (3), pp.338--44. ⟨10.1007/BF00186545⟩ |
| بيانات النشر: | HAL CCSD, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Chromosomes, Human, Pair 21, Pseudogene, Molecular Sequence Data, Receptor, Interferon alpha-beta, Biology, Mice, 03 medical and health sciences, Exon, 0302 clinical medicine, Chromosome 16, Sequence Homology, Nucleic Acid, Gene duplication, Genetics, Cytokine/*genetics Receptors, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Receptors, Cytokine, Molecular Biology, Gene, Ecology, Evolution, Behavior and Systematics, Receptors, Interferon, Repetitive Sequences, Nucleic Acid, 030304 developmental biology, Pair 21 *Genes Humans Interleukin-10 Receptor beta Subunit *Membrane Glycoproteins Mice Molecular Sequence Data Multigene Family Polymorphism, Animals Base Sequence Chromosome Mapping Chromosomes, 0303 health sciences, Membrane Glycoproteins, Polymorphism, Genetic, Base Sequence, Nucleic Acid Sequence Alignment Sequence Homology, Nucleic Acid, 030305 genetics & heredity, Intron, Chromosome Mapping, Interferon/*genetics Repetitive Sequences, Interleukin-10 Receptor beta Subunit, Genes, Multigene Family, 030220 oncology & carcinogenesis, Cytokine receptor, Chromosome 21, Sequence Alignment, Pseudogenes, Interferon alpha-beta Receptors, Genetic Pseudogenes Receptor, Human |
| الوصف: | The cytokine receptor family consists of a growing number of structurally and evolutionarily related transmembrane receptors. CRFB4 and IFNAR are two of the most similar members of this family. They are encoded by two neighboring genes on both human chromosome 21 and murine chromosome 16. The sequence of the human CRFB4 gene was determined from the first exon to the last intron. The nature of the repetitive sequences present in the introns was analyzed and compared with those present in the human IFNAR gene. This analysis leads to considerations of the antiquity of the duplication that gave rise to both genes from a common ancestor. A pseudogene for USF has been identified in the IFNAR gene and a new definition for the repetitive sequence MER37 is proposed. The polymorphism associated with two CA repeats present in the CRFB4 gene is described. |
| اللغة: | English |
| تدمد: | 0022-2844 1432-1432 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c3ba0a2e2909233b26db8c6bad09fc https://hal.archives-ouvertes.fr/hal-02192671 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....34c3ba0a2e2909233b26db8c6bad09fc |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 00222844 14321432 |
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