Toward the library generation of natural product-like polycyclic derivatives by stereocontrolled diversity-oriented synthesis
| العنوان: | Toward the library generation of natural product-like polycyclic derivatives by stereocontrolled diversity-oriented synthesis |
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| المؤلفون: | Donald M. Leek, Prabhat Arya, S. Quevillon, M. Parisien, Patricia Durieux, D. Laforce, L.-C. Campeau, Reni Joseph, Z.‐X. Chen, Zhonghong Gan, S. Khadem, R. Kumar, Chang-Qing Wei, Malgosia Daroszewska, Michael L. Barnes, U. Sharma, E. Sesmilo, Samuel Couve-Bonnaire, P. T. Reddy |
| المصدر: | Pure and Applied Chemistry. 77:163-178 |
| بيانات النشر: | Walter de Gruyter GmbH, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Protein function, Natural product, Chemistry, General Chemical Engineering, antifungal activity, lignans, piper species, neolignans, General Chemistry, Computational biology, Plasma protein binding, Small molecule, ICAM-1 inhibition, chemistry.chemical_compound, Biochemistry, Rapid access, aspergillosis, anti-inflammatory activity, long-chain esters and amides, Cell signaling pathways, medicinal plants |
| الوصف: | Due to the growing interest in small molecules that could help in understanding protein–protein interactions based on signal transduction, the demand for the generation of small-molecule libraries that are inspired by bioactive natural products has grown significantly. Many of these pathways are highly complex and present tremendous challenges with the use of classical tools. A rapid access to natural product-like small molecules having structural complexity and diversity is crucial for systematically dissecting the functions of complex protein networking and understanding cell signaling pathways. The complex nature, the three-dimensional architecture, and the number of protein binding functional groups presented in three-dimensional arrays are some of the attractive features to incorporate in small-molecule chemical probes to be used as modulators of protein function. |
| وصف الملف: | application/pdf |
| تدمد: | 1365-3075 0033-4545 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e763e2cf058529e8ccae2162dff4c3 https://doi.org/10.1351/pac200577010163 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....34e763e2cf058529e8ccae2162dff4c3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13653075 00334545 |
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