Complete genome sequence of Salmonella enterica serovar Typhimurium LT2
| العنوان: | Complete genome sequence of Salmonella enterica serovar Typhimurium LT2 |
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| المؤلفون: | Michael Nhan, Kenneth E. Sanderson, Phil Latreille, Neenu Grewal, Dan Layman, Andrea Holmes, Hui Sun, Webb Miller, Elizabeth Mulvaney, Richard K. Wilson, Shawn Leonard, Sandra W. Clifton, John Spieth, Liliana Florea, Ellen E. Ryan, Shunfang Hou, Kelsi Scott, Christine Nguyen, Robert H. Waterston, Tamberlyn Stoneking, Feiyu Du, Johar Ali, Mike Dante, Michael McClelland, Steffen Porwollik, Laura Courtney |
| المصدر: | Nature. 413:852-856 |
| بيانات النشر: | Springer Science and Business Media LLC, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | DNA, Bacterial, Salmonella typhimurium, Salmonella bongori, Serotype, Salmonella Vaccines, Sequence analysis, Molecular Sequence Data, Population, Virulence, Genome, Microbiology, Plasmid, Enterobacteriaceae, Species Specificity, Escherichia coli, Animals, Humans, education, education.field_of_study, Multidisciplinary, biology, Sequence Analysis, DNA, Chromosomes, Bacterial, biology.organism_classification, Genes, Bacterial, Salmonella enterica, Fimbriae, Bacterial, bacteria, Genome, Bacterial, Pseudogenes, Plasmids |
| الوصف: | Salmonella enterica subspecies I, serovar Typhimurium (S. typhimurium), is a leading cause of human gastroenteritis, and is used as a mouse model of human typhoid fever. The incidence of non-typhoid salmonellosis is increasing worldwide, causing millions of infections and many deaths in the human population each year. Here we sequenced the 4,857-kilobase (kb) chromosome and 94-kb virulence plasmid of S. typhimurium strain LT2. The distribution of close homologues of S. typhimurium LT2 genes in eight related enterobacteria was determined using previously completed genomes of three related bacteria, sample sequencing of both S. enterica serovar Paratyphi A (S. paratyphi A) and Klebsiella pneumoniae, and hybridization of three unsequenced genomes to a microarray of S. typhimurium LT2 genes. Lateral transfer of genes is frequent, with 11% of the S. typhimurium LT2 genes missing from S. enterica serovar Typhi (S. typhi), and 29% missing from Escherichia coli K12. The 352 gene homologues of S. typhimurium LT2 confined to subspecies I of S. enterica-containing most mammalian and bird pathogens-are useful for studies of epidemiology, host specificity and pathogenesis. Most of these homologues were previously unknown, and 50 may be exported to the periplasm or outer membrane, rendering them accessible as therapeutic or vaccine targets. |
| تدمد: | 1476-4687 0028-0836 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f0d6aab86603086a58562a9a13b5e9 https://doi.org/10.1038/35101614 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....34f0d6aab86603086a58562a9a13b5e9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14764687 00280836 |
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