Dietary pattern, colonic microbiota and immunometabolism interaction: new frontiers for diabetes mellitus and related disorders
| العنوان: | Dietary pattern, colonic microbiota and immunometabolism interaction: new frontiers for diabetes mellitus and related disorders |
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| المؤلفون: | Nazarii Kobyliak, Aisa Bahar, Maral Hemati, Fatemeh Mehranfar, Z Rasouli Nejad, Majid Eslami, S Karami, Bahman Yousefi |
| المصدر: | Diabetic Medicine. 38 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Lipopolysaccharides, Colon, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Carbohydrate metabolism, Bioinformatics, Bile Acids and Salts, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Diabetes mellitus, Internal Medicine, medicine, Humans, Glucose homeostasis, Secretion, 030212 general & internal medicine, Microbiome, Inflammation, business.industry, Fatty Acids, Volatile, medicine.disease, Diet, Gastrointestinal Microbiome, Diabetes Mellitus, Type 2, Cytokines, Dysbiosis, business, Amino Acids, Branched-Chain, Homeostasis |
| الوصف: | In this review, the numerous possible mechanisms that provide supportive evidence for how colonic dysbiosis denotes metabolic dysfunction, dysregulates glucose homeostasis and leads to diabetes mellitus and related metabolic disorders are defined. Information was gathered from articles identified by systematic reviews and searches using Google, PubMed and Scopus. The composition of the colonic microbiota plays an integral role in maintaining host homeostasis by affecting both metabolic activities and underlying functional gene transcription in individuals with diabetes and related metabolic disorders. Increased colonic microbiome-derived concentrations of lipopolysaccharides, also known as 'metabolic endotoxaemia', as well as alterations in bile acid metabolism, short-chain fatty acids, intestinal hormones and branched-chain amino acid secretion have been associated with the diverse production of pro-inflammatory cytokines and the recruitment of inflammatory cells. It has been shown that changes to intestinal bacterial composition are significant even in early childhood and are associated with the pathogenesis of both types of diabetes. We hope that an improved understanding of related mechanisms linking the colonic microbiome with glucose metabolism might provide for innovative therapeutic approaches that would bring the ideal intestinal ecosystem to a state of optimal health, thus preventing and treating diabetes and related metabolic disorders. |
| تدمد: | 1464-5491 0742-3071 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350996ca9e20484cb83ae6829892218d https://doi.org/10.1111/dme.14415 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....350996ca9e20484cb83ae6829892218d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14645491 07423071 |
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