ESMO consensus conference on malignant lymphoma: general perspectives and recommendations for prognostic tools in mature B-cell lymphomas and chronic lymphocytic leukaemia
| العنوان: | ESMO consensus conference on malignant lymphoma: general perspectives and recommendations for prognostic tools in mature B-cell lymphomas and chronic lymphocytic leukaemia |
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| المؤلفون: | M. Ladetto, C. Buske, M. Hutchings, M. Dreyling, G. Gaidano, S. Le Gouill, S. Luminari, C. Pott, A. Zamò, E. Zucca, A.J.M. Ferreri, P. Fields, V. Goede, S.L. Gouill, U. Mey, P.d.N. Brown, M. Pfreundschuh, N. Schmitz, P. Soubeyran, M. Spina, R. Stauder, A.S. Balari, M. Trněný, G.v. Imhoff, J. Walewski, U. Wedding |
| المساهمون: | Hematology Division, Azienda Ospedaliera Santi Antonio e Biagio e Cesare Arrigo, Comprehensive Cancer Center [Ulm], Institute of Experimental Cancer Research, Universitätsklinikum Ulm - University Hospital of Ulm, Rigshospitalet [Copenhagen], Copenhagen University Hospital, III. Medizinische Klinik, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Università degli Studi del Piemonte Orientale - Amedeo Avogadro (UPO), Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, University Hospital Schleswig-Holstein, Department of Diagnostics and Public Health, University of Verona (UNIVR), Oncology Institute of Southern Switzerland, ESMO Lymphoma Consensus Conference Panel Members, Bernardo, Elizabeth, Università degli studi di Verona = University of Verona (UNIVR) |
| المصدر: | Annals of Oncology Annals of Oncology, Elsevier, 2016, ⟨10.1093/annonc/mdw419⟩ Annals of Oncology, 2016, ⟨10.1093/annonc/mdw419⟩ |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, positron emission tomography, Mature B-Cell, MEDLINE, TP53, cell of origin, consensus, lymphoma, minimal residual disease, Context (language use), [SDV.CAN]Life Sciences [q-bio]/Cancer, Scientific literature, Malignant lymphoma, 03 medical and health sciences, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, Interim, Internal medicine, Medicine, Medical physics, 030304 developmental biology, 0303 health sciences, Lymphocytic leukaemia, business.industry, Consensus conference, Evidence-based medicine, Hematology, Minimal residual disease, 3. Good health, Clinical trial, 030220 oncology & carcinogenesis, Immunology, Working group, business, 030215 immunology |
| الوصف: | International audience; The European Society for Medical Oncology (ESMO) consensus conference on mature B-cell lymphomas and chronic lymphocytic leukaemia (CLL) was held on 20 June 2015 in Lugano, Switzerland, and included a multidisciplinary panel of 25 leading experts. The aim of the conference was to develop recommendations on critical subjects difficult to consider in detail in the ESMO Clinical Practice Guidelines. The following areas were identified: (i) the elderly patient, (ii) prognostic factors suitable for clinical use and (iii) the 'ultra-high-risk' group. Before the conference, the expert panel was divided into three working groups; each group focused on one of these areas in order to address four clinically relevant questions relating to that topic. All relevant scientific literature, as identified by the experts, was reviewed in advance. During the consensus conference, each working group developed recommendations to address each of the four questions assigned to their group. These recommendations were then presented to the entire panel and a consensus was reached. This manuscript presents recommendations dedicated to the second area of interest, i.e. prognostic factors suitable for clinical use. The four topics [i.e. interim positron emission tomography (PET), TP53 mutations, cell of origin (COO) and minimal residual disease (MRD)] were primarily chosen because of the bulk of available data together with the lack of clear guidance regarding their use in clinical practice and within clinical trials. Results, including a summary of evidence supporting each recommendation, are detailed in this manuscript. The panel acknowledged that detection of TP53 inactivation by deletion or mutation in CLL should be implemented in clinical practice (level of evidence I, strength of recommendation A). Due to their potentially high prognostic value, at least in some lymphoma entities, implementation of interim PET, COO and MRD was highly recommended in the context of clinical trials. All expert panel members approved this final article. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0923-7534 1569-8041 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350e3fb5413b1e1c6994100883315911 http://hdl.handle.net/11562/950069 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....350e3fb5413b1e1c6994100883315911 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09237534 15698041 |
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