25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2
| العنوان: | 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2 |
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| المؤلفون: | Franco Keller, Jessica Cusato, Renzo Lucchini, Marco Cantù, Alessandra Manca, Antonio D'Avolio, Valeria Avataneo, Amedeo De Nicolò |
| المصدر: | Nutrients, Vol 12, Iss 1359, p 1359 (2020) Nutrients, 12(5):1359 Nutrients |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 2019-20 coronavirus outbreak, Concentrations, Coronavirus, COVID-19, Deficiency, SARS-CoV-2, Vitamin D, Age Factors, Aged, Aged, 80 and over, Betacoronavirus, Coronavirus Infections, Dietary Supplements, Female, Humans, Middle Aged, Pandemics, Pneumonia, Viral, Polymerase Chain Reaction, Retrospective Studies, Switzerland, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus, vitamin D, lcsh:TX341-641, concentrations, deficiency, medicine.disease_cause, law.invention, law, Pandemic, medicine, Vitamin D and neurology, 80 and over, In patient, Viral, Polymerase chain reaction, Nutrition and Dietetics, biology, business.industry, Brief Report, Pneumonia, biology.organism_classification, Virology, business, lcsh:Nutrition. Foods and food supply, Food Science |
| الوصف: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), with a clinical outcome ranging from mild to severe, including death. To date, it is unclear why some patients develop severe symptoms. Many authors have suggested the involvement of vitamin D in reducing the risk of infections; thus, we retrospectively investigated the 25-hydroxyvitamin D (25(OH)D) concentrations in plasma obtained from a cohort of patients from Switzerland. In this cohort, significantly lower 25(OH)D levels (p = 0.004) were found in PCR-positive for SARS-CoV-2 (median value 11.1 ng/mL) patients compared with negative patients (24.6 ng/mL); this was also confirmed by stratifying patients according to age >70 years. On the basis of this preliminary observation, vitamin D supplementation might be a useful measure to reduce the risk of infection. Randomized controlled trials and large population studies should be conducted to evaluate these recommendations and to confirm our preliminary observation. |
| اللغة: | English |
| تدمد: | 2072-6643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350ed99d6a5fc6941d76ed654424ca31 https://www.mdpi.com/2072-6643/12/5/1359 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....350ed99d6a5fc6941d76ed654424ca31 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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