TGFβ Type II Receptor Signaling Controls Schwann Cell Death and Proliferation in Developing Nerves
| العنوان: | TGFβ Type II Receptor Signaling Controls Schwann Cell Death and Proliferation in Developing Nerves |
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| المؤلفون: | Anna Droggiti, M Laura Feltri, Kristjan R. Jessen, Rhona Mirsky, Jürgen Roes, Maurizio D'Antonio, Lawrence Wrabetz |
| المصدر: | The Journal of Neuroscience. 26:8417-8427 |
| بيانات النشر: | Society for Neuroscience, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Nerve Crush, Neuregulin-1, Down-Regulation, Embryonic Development, Schwann cell, Nerve Tissue Proteins, Protein Serine-Threonine Kinases, Biology, Schwann cell proliferation, Mice, Growth factor receptor, TGF beta signaling pathway, medicine, Animals, Receptor, Cells, Cultured, Myelin Sheath, Cell Proliferation, Mice, Knockout, Cell Death, Cell growth, General Neuroscience, Receptor, Transforming Growth Factor-beta Type II, Axotomy, Drug Synergism, Articles, Embryo, Mammalian, Sciatic Nerve, Cell biology, medicine.anatomical_structure, Animals, Newborn, nervous system, Immunology, Neuregulin, Schwann Cells, Receptors, Transforming Growth Factor beta, Signal Transduction, Transforming growth factor |
| الوصف: | During development, Schwann cell numbers are precisely adjusted to match the number of axons. It is essentially unknown which growth factors or receptors carry out this important controlin vivo. Here, we tested whether the type II transforming growth factor (TGF) β receptor has a role in this process. We generated a conditional knock-out mouse in which the type II TGFβ receptor is specifically ablated only in Schwann cells. Inactivation of the receptor, evident at least from embryonic day 18, resulted in suppressed Schwann cell death in normally developing and injured nerves. Notably, the mutants also showed a strong reduction in Schwann cell proliferation. Consequently, Schwann cell numbers in wild-type and mutant nerves remained similar. Lack of TGFβ signaling did not appear to affect other processes in which TGFβ had been implicated previously, including myelination and response of adult nerves to injury. This is the firstin vivoevidence for a growth factor receptor involved in promoting Schwann cell division during development and the first genetic evidence for a receptor that controls normal developmental Schwann cell death. |
| تدمد: | 1529-2401 0270-6474 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3515aa235433d02feee8904d17681592 https://doi.org/10.1523/jneurosci.1578-06.2006 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3515aa235433d02feee8904d17681592 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292401 02706474 |
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