Effect of islet transplantation on the glomerular changes in streptozotocin-diabetic rats
| العنوان: | Effect of islet transplantation on the glomerular changes in streptozotocin-diabetic rats |
|---|---|
| المؤلفون: | W. Kösters, M. Strauch, M. Staudenmeir, H. Wehner |
| المصدر: | Virchows Archiv A Pathological Anatomy and Histology. 388:137-154 |
| بيانات النشر: | Springer Science and Business Media LLC, 1980. |
| سنة النشر: | 1980 |
| مصطلحات موضوعية: | Blood Glucose, Male, medicine.medical_specialty, Histology, Kidney Glomerulus, Islets of Langerhans Transplantation, Antigen-Antibody Complex, urologic and male genital diseases, Basement Membrane, Diabetes Mellitus, Experimental, Pathology and Forensic Medicine, Diabetes mellitus, Internal medicine, medicine, Animals, Molecular Biology, geography, geography.geographical_feature_category, Streptozotocin Diabetes, Portal Vein, urogenital system, business.industry, Glomerulosclerosis, Cell Biology, General Medicine, Metabolism, Streptozotocin, Islet, medicine.disease, female genital diseases and pregnancy complications, Rats, Transplantation, Transplantation, Isogeneic, Endocrinology, Mesangium, Anatomy, business, medicine.drug |
| الوصف: | Glomerular changes develop in rats with streptozotocin diabetes. The structure of these lesions (nodular and diffuse glomerulosclerosis, mesangial cell proliferation, basement membrane thickening, glomerular aneurysms, fibrinoid caps, glomerular adhesions) is described in the present paper and the effect of normalization of metabolism by islet transplantation on the glomerular changes is studied with histological, immunohistological and morphometric methods. Isogenous islets were transplanted into the portal vein of streptozotocin-diabetic rats after diabetes of 7 months' duration. The kidneys of normal, diabetic and transplanted animals of the same age were studied 2.5 months later. Studies of the kinetics of immunocomplexes in the mesangium were also performed. The renal changes (glomerulosclerosis, mesangial cell proliferation) were largely reversible after islet transplantation and the blood glucose level and glucose tolerance were normalized. In the diabetic animals the delayed uptake and elimination of immunocomplexes in the mesangium was normalized after the transplantation. It is possible, that the cause of the lesions is a functional disturbance of the mesangium induced by insulin deficiency and/or hyperglycaemia. |
| تدمد: | 1432-2307 0340-1227 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354ea0cf6c37f6f750dd97bc8d16fbef https://doi.org/10.1007/bf00430683 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....354ea0cf6c37f6f750dd97bc8d16fbef |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14322307 03401227 |
|---|