δ-(l -α-aminoadipyl)-l -cysteinyl-d -valine synthetase (ACVS): discovery and perspectives
| العنوان: | δ-( |
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| المؤلفون: | Kapil Tahlan, Marcus A. Moore, Susan E. Jensen |
| المصدر: | Journal of Industrial Microbiology and Biotechnology. 44:517-524 |
| بيانات النشر: | Oxford University Press (OUP), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Stereochemistry, viruses, ACV synthetase, Genes, Fungal, Bioengineering, Tripeptide, Penicillium chrysogenum, Biology, Applied Microbiology and Biotechnology, Streptomyces, 03 medical and health sciences, Bacterial Proteins, Valine, β lactams, Protein purification, Peptide Synthases, skin and connective tissue diseases, chemistry.chemical_classification, 030102 biochemistry & molecular biology, virus diseases, biology.organism_classification, 030104 developmental biology, Enzyme, Biochemistry, chemistry, Genes, Bacterial, biology.protein, Oligopeptides, Large size, Biotechnology |
| الوصف: | The δ-(l-α-aminoadipyl)-l-cysteinyl-d-valine (ACV) tripeptide is the first dedicated intermediate in the biosynthetic pathway leading to the penicillin and cephalosporin classes of β-lactam natural products in bacteria and fungi. It is synthesized nonribosomally by the ACV synthetase (ACVS) enzyme, which has been purified and partially characterized from many sources. Due to its large size and instability, many details regarding the reaction mechanism of ACVS are still not fully understood. In this review we discuss the chronology and associated methodology that led to the discovery of ACVS, some of the main findings regarding its activities, and some recent/current studies being conducted on the enzyme. In addition, we conclude with perspectives on what can be done to increase our understating of this very important protein in the future. |
| تدمد: | 1476-5535 1367-5435 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35595a1a09878cbeedaba850b21bd951 https://doi.org/10.1007/s10295-016-1850-7 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....35595a1a09878cbeedaba850b21bd951 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14765535 13675435 |
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