Tumor suppressor p53 plays a key role in induction of bothtristetraprolin and let-7 in human cancer cells
| العنوان: | Tumor suppressor p53 plays a key role in induction of bothtristetraprolin and let-7 in human cancer cells |
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| المؤلفون: | Wha Ja Cho, Aran Lee, Hee Jeong Cha, Young Joo Min, Nal Ae Yoon, Hyo Jeong Kim, Ji Young Lee, Won Hyeok Lee, Byung Ju Lee, Jeong Woo Park, Byung Kyun Ko |
| المصدر: | NUCLEIC ACIDS RESEARCH(41): 11 Nucleic Acids Research |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | DNA damage, Tristetraprolin, Biology, Adenocarcinoma, Gene Regulation, Chromatin and Epigenetics, medicine.disease_cause, Cell Line, Tumor, hemic and lymphatic diseases, microRNA, Genetics, medicine, Humans, heterocyclic compounds, Promoter Regions, Genetic, neoplasms, Cell Proliferation, Mutation, Cell growth, Cancer, RNA-Binding Proteins, respiratory system, medicine.disease, Molecular biology, Gene Expression Regulation, Neoplastic, MicroRNAs, Doxorubicin, Cancer cell, Colonic Neoplasms, Cancer research, Tumor Suppressor Protein p53, Carcinogenesis, therapeutics |
| الوصف: | Tristetraprolin (TTP) and let-7 microRNA exhibit suppressive effects on cell growth through down-regulation of oncogenes. Both TTP and let-7 are often repressed in human cancers, thereby promoting oncogenesis by derepressing their target genes. However, the precise mechanism of this repression is unknown. We here demonstrate that p53 stimulated by the DNA-damaging agent doxorubicin (DOX) induced the expression of TTP in cancer cells. TTP in turn increased let-7 levels through down-regulation of Lin28a. Correspondingly, cancer cells with mutations or inhibition of p53 failed to induce the expression of both TTP and let-7 on treatment with DOX. Down-regulation of TTP by small interfering RNAs attenuated the inhibitory effect of DOX on let-7 expression and cell growth. Therefore, TTP provides an important link between p53 activation induced by DNA damage and let-7 biogenesis. These novel findings provide a mechanism for the widespread decrease in TTP and let-7 and chemoresistance observed in human cancers. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356c56fc72fd397fb2eb3af74d7807d4 http://open-repository.kisti.re.kr/cube/handle/open_repository/486545.do |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....356c56fc72fd397fb2eb3af74d7807d4 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |