Algal Oil Rich in Docosahexaenoic Acid Alleviates Intestinal Inflammation Induced by Antibiotics Associated with the Modulation of the Gut Microbiome and Metabolome
| العنوان: | Algal Oil Rich in Docosahexaenoic Acid Alleviates Intestinal Inflammation Induced by Antibiotics Associated with the Modulation of the Gut Microbiome and Metabolome |
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| المؤلفون: | Zhixian Qiao, Zhenxia Xu, Xu Wang, Chen Yang, Qianchun Deng, Chen Wenchao, Fenghong Huang |
| المصدر: | Journal of Agricultural and Food Chemistry. 69:9124-9136 |
| بيانات النشر: | American Chemical Society (ACS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Inflammation, Docosahexaenoic Acids, biology, Chemistry, Ruminococcus, fungi, Metabolic disorder, General Chemistry, Metabolism, Gut flora, medicine.disease, biology.organism_classification, Anti-Bacterial Agents, Gastrointestinal Microbiome, Microbiology, Docosahexaenoic acid, Metabolome, medicine, Humans, General Agricultural and Biological Sciences, Dysbiosis, Bacteria |
| الوصف: | In this study, the effect of algal oil rich in docosahexaenoic acid on the mucosal injury with gut microbiota disorders caused by ceftriaxone sodium (CS) was evaluated. The results showed that algal oil treatment (500 mg kg-1 day-1) significantly reduced the levels of pro-inflammatory cytokines, including interleukin 6 , interleukin 1β, and tumor necrosis factor α, in the colon. Algal oil restored the CS-induced gut microbiota dysbiosis by elevating some short-chain-fatty-acid-producing bacteria, e.g., Ruminococcus and Blautia. The CS-induced metabolic disorder was also regulated by algal oil, which was characterized by the modulations of tryptophan metabolism, phospholipid metabolism, and bile acid metabolism. Our results suggested that supplementation of algal oil could alleviate inflammation and promote mucosal healing, which could be a functional food ingredient to protect aganist antibiotic-induced alteration of gut microbiota and metabolic dysbiosis. |
| تدمد: | 1520-5118 0021-8561 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3578d2d1fbc942bea1577864a5facade https://doi.org/10.1021/acs.jafc.0c07323 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....3578d2d1fbc942bea1577864a5facade |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15205118 00218561 |
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