Slow Wave Sleep Enhancement with Gaboxadol Reduces Daytime Sleepiness During Sleep Restriction
| العنوان: | Slow Wave Sleep Enhancement with Gaboxadol Reduces Daytime Sleepiness During Sleep Restriction |
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| المؤلفون: | Janine Hall, Paula K. Schweitzer, John A. Groeger, Ellen Snyder, Rhody D. Eisenstein, Angela C. Randazzo, Stephen D. Feren, Kara S. Griffin, Pam Dickey, James K. Walsh |
| المصدر: | Scopus-Elsevier |
| بيانات النشر: | Oxford University Press (OUP), 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, Multiple Sleep Latency Test, Epinephrine, Hydrocortisone, Polysomnography, Disorders of Excessive Somnolence, Neuropsychological Tests, Norepinephrine, Double-Blind Method, Physiology (medical), Reaction Time, medicine, Humans, Attention, GABA Agonists, Fatigue, Sleep restriction, Slow-wave sleep, Fourier Analysis, medicine.diagnostic_test, Psychomotor vigilance task, Electroencephalography, Isoxazoles, Sleep in non-human animals, Circadian Rhythm, Affect, Sleep deprivation, Slow Wave Sleep Enhancement and Daytime Sleepiness, Anesthesia, Mental Recall, Sleep Deprivation, Female, Neurology (clinical), medicine.symptom, Arousal, Sleep, Psychology, Psychomotor Performance, Somnolence |
| الوصف: | Study objectives: To evaluate the impact of enhanced slow wave sleep (SWS) on behavioral, psychological, and physiological changes resulting from sleep restriction. design: A double-blind, parallel group, placebo-controlled design was used to compare gaboxadol (GBX) 15 mg, a SWS-enhancing drug, to placebo during 4 nights of sleep restriction (5 h/night). Behavioral, psy- chological, and physiological measures of the impact of sleep restriction were assessed in both groups at baseline, during sleep restriction and following recovery sleep. Setting: Sleep research laboratory. participants: Forty-one healthy adults; 9 males and 12 females (mean age: 32.0 ± 9.9 y) in the placebo group and 10 males and 10 females (mean age: 31.9 ± 10.2 y) in the GBX group. interventions: Both experimental groups underwent 4 nights of sleep restriction. Each group received either GBX 15 mg or placebo on all sleep restriction nights, and both groups received placebo on baseline and recovery nights. measurements and Results: Polysomnography documented a SWS- enhancing effect of GBX with no group difference in total sleep time dur- ing sleep restriction. The placebo group displayed the predicted deficits due to sleep restriction on the multiple sleep latency test (MSLT) and on introspective measures of sleepiness and fatigue. Compared to place- bo, the GBX group showed significantly less physiological sleepiness on the MSLT and lower levels of introspective sleepiness and fatigue during sleep restriction. There were no differences between groups on the psychomotor vigilance task (PVT) and a cognitive test battery, but these measures were minimally affected by sleep restriction in this study. The correlation between change from baseline in MSLT on Day 6 and change from baseline in SWS on Night 6 was significant in the GBX group and in both groups combined. conclusions: The results of this study are consistent with the hypothe- sis that enhanced SWS, in this study produced by GBX, reduces physi- ological sleep tendency and introspective sleepiness and fatigue which typically result from sleep restriction. |
| تدمد: | 1550-9109 0161-8105 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3590cfcbc6455285d72b31bbc375d657 https://doi.org/10.1093/sleep/31.5.659 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3590cfcbc6455285d72b31bbc375d657 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15509109 01618105 |
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