Atomistic study of lipid membranes containing chloroform: looking for a lipid-mediated mechanism of anesthesia
| العنوان: | Atomistic study of lipid membranes containing chloroform: looking for a lipid-mediated mechanism of anesthesia |
|---|---|
| المؤلفون: | Ramon Reigada |
| المساهمون: | Universitat de Barcelona |
| المصدر: | Recercat. Dipósit de la Recerca de Catalunya instname PLoS ONE PLoS ONE, Vol 8, Iss 1, p e52631 (2013) Dipòsit Digital de la UB Universidad de Barcelona |
| بيانات النشر: | Public Library of Science (PLoS) |
| مصطلحات موضوعية: | Lipid Bilayers, lcsh:Medicine, Molecular Dynamics, Biochemistry, Biophysics Simulations, Cell membrane, chemistry.chemical_compound, Molecular dynamics, Computational Chemistry, Halogens, Anesthesiology, Molecular Cell Biology, Electrochemistry, Anesthesia, Organic Chemicals, lcsh:Science, Lipid bilayer, Carbon Tetrachloride, Membrane potential, Multidisciplinary, Chloroform, Chemistry, Membrane, medicine.anatomical_structure, Cytochemistry, Phosphatidylcholines, Medicine, Thermodynamics, Membranes and Sorting, lipids (amino acids, peptides, and proteins), Research Article, medicine.drug, Static Electricity, Biophysics, Anesthetic Mechanisms, Membrane Lipids, medicine, Molecule, Computer Simulation, Biology, Cloroform, Chemical Physics, Anesthesiology Technology, Membranes, lcsh:R, Cell Membrane, Anestèsia, Lipid membranes, Membranes lipídiques, chemistry, Anesthetic, lcsh:Q |
| الوصف: | The molecular mechanism of general anesthesia is still a controversial issue. Direct effect by linking of anesthetics to proteins and indirect action on the lipid membrane properties are the two hypotheses in conflict. Atomistic simulations of different lipid membranes subjected to the effect of small volatile organohalogen compounds are used to explore plausible lipid-mediated mechanisms. Simulations of homogeneous membranes reveal that electrostatic potential and lateral pressure transversal profiles are affected differently by chloroform (anesthetic) and carbon tetrachloride (non-anesthetic). Simulations of structured membranes that combine ordered and disordered regions show that chloroform molecules accumulate preferentially in highly disordered lipid domains, suggesting that the combination of both lateral and transversal partitioning of chloroform in the cell membrane could be responsible of its anesthetic action. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35966d6bb77881c6a2ffcf9b95051b2c http://hdl.handle.net/2445/124531 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....35966d6bb77881c6a2ffcf9b95051b2c |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |