The Relationship between Secondary Structure and Biodegradation Behavior of Silk Fibroin Scaffolds
| العنوان: | The Relationship between Secondary Structure and Biodegradation Behavior of Silk Fibroin Scaffolds |
|---|---|
| المؤلفون: | Mingzhong Li, Qin Zhang, Yongpei Hu, Renchuan You, Lingshuang Wang |
| المصدر: | Advances in Materials Science and Engineering, Vol 2012 (2012) |
| بيانات النشر: | Hindawi Limited, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Scaffold, Materials science, Article Subject, Biocompatibility, fungi, General Engineering, Fibroin, Matrix (biology), Biodegradation, Chemical engineering, Tissue engineering, lcsh:TA401-492, lcsh:Materials of engineering and construction. Mechanics of materials, General Materials Science, Fourier transform infrared spectroscopy, Protein secondary structure |
| الوصف: | Silk fibroin has a unique and useful combination of properties, including good biocompatibility and excellent mechanical performance. These features provided early clues to the utility of regenerated silk fibroin as a scaffold/matrix for tissue engineering. The silk fibroin scaffolds used for tissue engineering should degrade at a rate that matches the tissue growth rate. The relationship between secondary structure and biodegradation behavior of silk fibroin scaffolds was investigated in this study. Scaffolds with different secondary structure were prepared by controlling the freezing temperature and by treatment with carbodiimide or ethanol. The quantitative proportions of each secondary structure were obtained by Fourier transform infrared spectroscopy (FTIR), and each sample was then degradedin vitrowith collagenase IA for 18 days. The results show that a high content ofβ-sheet structure leads to a low degradation rate. The random coil region in the silk fibroin material is degraded, whereas the crystal region remains stable and the amount ofβ-sheet structure increases during incubation. The results demonstrate that it is possible to control the degradation rate of a silk fibroin scaffold by controlling the content ofβ-sheet structure. |
| وصف الملف: | text/xhtml |
| تدمد: | 1687-8442 1687-8434 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359acc44cc9def1b812068aace8fe199 https://doi.org/10.1155/2012/185905 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....359acc44cc9def1b812068aace8fe199 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16878442 16878434 |
|---|