A 90-Day Repeated Oral Dose Toxicity Study of Alismatis Rhizoma Aqueous Extract in Rats
| العنوان: | A 90-Day Repeated Oral Dose Toxicity Study of Alismatis Rhizoma Aqueous Extract in Rats |
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| المؤلفون: | Ho-Kyung Jung, Mu-Jin Lee, Seong-Ho Ham, Jong-Choon Kim, Sung-Jin Park, Kiho Lee, Ji-Hun Jang, Je-Won Ko, Jin-Han Shon, Tea-Gyeong Seong, Yong-Min Kim, Byung-Kwan Ahn, Mi-Ok Sim, Ji-Young Yoon, Hyun-Woo Cho |
| المصدر: | Toxicological Research |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | NOAEL, Health, Toxicology and Mutagenesis, medicine.medical_treatment, ved/biology.organism_classification_rank.species, 010501 environmental sciences, Hematocrit, Pharmacology, Toxicology, 030226 pharmacology & pharmacy, 01 natural sciences, Alismatis rhizome aqueous extract, Sub-chronic toxicity, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Oral administration, medicine, Alisma orientale, Diuretic effect, 0105 earth and related environmental sciences, medicine.diagnostic_test, ved/biology, Cholesterol, business.industry, Albumin, Traditional medicine, chemistry, Toxicity, Original Article, Hemoglobin, Diuretic, business |
| الوصف: | Alismatis rhizoma (AR), the dried rhizome of Alisma orientale (Sam.) Juzep, is a well-known, traditional medicine that is used for the various biological activities including as a diuretic, to lower cholesterol and as an anti-inflammatory agent. The present study was carried out to investigate the potential toxicity of the Alismatis rhizoma aqueous extract (ARAE) following 90-day repeated oral administration to Sprague-Dawley rats. ARAE was administered orally to male and female rats for 90 days at 0 (control), 500, 1,000 and 2,000 mg/kg/day (n = 10 for male and female rats for each dose). Additional recovery groups from the control group and high dose group were observed for a 28-day recovery period. Chromatograms of ARAE detected main compounds with four peaks. Treatment-related effects including an increase in the red blood cells, hemoglobin, hematocrit, albumin, total protein, and urine volume were observed in males of the 2,000 mg/kg/day group (p < 0.05). However, the diuretic effect of ARAE was considered, a major cause of hematological and serum biochemical changes. The oral no-observed-adverse-effect level (NOAEL) of the ARAE was > 2,000 mg/kg/day in both genders, and no target organs were identified. |
| تدمد: | 2234-2753 1976-8257 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c0cbd095272339819c0b19421bc5a9 https://doi.org/10.5487/tr.2019.35.2.191 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....35c0cbd095272339819c0b19421bc5a9 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 22342753 19768257 |
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