Systemic Sarcoidosis Associated with Certolizumab Pegol Treatment for Rheumatoid Arthritis: A Case Report and Review of the Literature
| العنوان: | Systemic Sarcoidosis Associated with Certolizumab Pegol Treatment for Rheumatoid Arthritis: A Case Report and Review of the Literature |
|---|---|
| المؤلفون: | Keigo Koda, Tsuyoshi Nozue, Takafumi Suda, Mikio Toyoshima |
| المصدر: | Internal Medicine |
| بيانات النشر: | Japanese Society of Internal Medicine, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Sarcoidosis, Mediastinal lymphadenopathy, Lymphocytosis, Case Report, 030204 cardiovascular system & hematology, Gastroenterology, Arthritis, Rheumatoid, Uveitis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Internal Medicine, medicine, Humans, Certolizumab pegol, Lung, Aged, Granuloma, medicine.diagnostic_test, business.industry, Mediastinum, General Medicine, respiratory system, medicine.disease, humanities, certolizumab pegol, medicine.anatomical_structure, Bronchoalveolar lavage, anti-tumor necrosis factor-α agent, Rheumatoid arthritis, Female, 030211 gastroenterology & hepatology, Lymph Nodes, medicine.symptom, Tomography, X-Ray Computed, business, Bronchoalveolar Lavage Fluid, medicine.drug |
| الوصف: | A 69-year-old woman presented with appetite loss, fatigue, and a low-grade fever. She had been receiving certolizumab pegol for rheumatoid arthritis for six years. Computed tomography of the chest showed multiple micronodules in both lungs and bilateral hilar and mediastinal lymphadenopathy. An ophthalmic examination showed the findings of uveitis. Lymphocytosis with an increased CD4/CD8 ratio was seen in the bronchoalveolar lavage fluid. Video-assisted thoracoscopic biopsy specimens obtained from the right lung and a right hilar lymph node showed noncaseous epithelioid cell granulomas. Anti-tumor necrosis factor-α-induced sarcoidosis was diagnosed, and she was successfully treated with cessation of certolizumab pegol and systemic corticosteroid therapy. |
| تدمد: | 1349-7235 0918-2918 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ff16c00a24bf3bcbff6907879bb045 https://doi.org/10.2169/internalmedicine.4275-19 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....35ff16c00a24bf3bcbff6907879bb045 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497235 09182918 |
|---|