Assessment of self-reported and objective daytime sleepiness in adult-onset myotonic dystrophy type 1
| العنوان: | Assessment of self-reported and objective daytime sleepiness in adult-onset myotonic dystrophy type 1 |
|---|---|
| المؤلفون: | Luca Mauro, A. Zanolini, Elisa Falcier, Fabio Placidi, Annalisa Rubino, Elisabetta Roma, Federica Amico, Claudio Liguori, Andrea Romigi, Elio Agostoni, Carola Ferrari Aggradi, Paola Rogliani, Francesca Izzi, Federica Cattaneo, Valeria A. Sansone, Matteo Spanetta, Fabrizio Rao, Paola Proserpio, Andrea Lizio Biost, Erica Frezza, Lino Nobili, Roberto Massa, Andrea Lanza, Claudia Galluzzi, Gabriella Pezzuto, Giulia Greco, Alice Pirola |
| المصدر: | J Clin Sleep Med Web of Science |
| بيانات النشر: | American Academy of Sleep Medicine (AASM), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Pulmonary and Respiratory Medicine, Multiple Sleep Latency Test, Pediatrics, medicine.medical_specialty, Sleepiness, Polysomnography, Concordance, Excessive daytime sleepiness, Disorders of Excessive Somnolence, Settore MED/26, Myotonic dystrophy, Quality of life, medicine, Sleep Protocols, Humans, Myotonic Dystrophy, Wakefulness, myotonic dystrophy type 1, medicine.diagnostic_test, business.industry, excessive daytime sleepiness, Epworth Sleepiness Scale, polysomnography, Quality of Life, Self Report, medicine.disease, Scientific Investigations, Neurology, Neurology (clinical), medicine.symptom, business |
| الوصف: | STUDY OBJECTIVES: Excessive daytime sleepiness (EDS) in myotonic dystrophy type 1 is mostly of central origin but it may coexist with sleep-related breathing disorders. However, there is no consensus on the sleep protocols to be used, assessments vary, and only a minority of patients are regularly tested or are on treatment for EDS. Our study presents data on self-reported and objective EDS in adult-onset myotonic dystrophy type 1. METHODS: Sixty-three patients with adult-onset DM1 were subjected to EDS-sleep assessments (polysomnography, Multiple Sleep Latency Test, Epworth Sleepiness Scale). Correlation coefficients were computed to assess the relationship between sleep and sleepiness test results, fatigue, and quality of life. RESULTS: 33% and 48% of patients had EDS based, respectively, on the Epworth Sleepiness Scale and the Multiple Sleep Latency Test, with a low concordance between these tests (k = 0.19). Thirteen patients (20%) displayed 2 or more sleep-onset rapid eye movement periods on Multiple Sleep Latency Test. Patients having EDS by Multiple Sleep Latency Test had a shorter disease duration (P < .05), higher total sleep time and sleep efficiency and lower wake after sleep onset on polysomnography. Patients with self-reported EDS reported significantly higher fatigue score compared with patients without EDS (P < .05). No other difference was found in demographic, clinical, and respiratory features. CONCLUSIONS: EDS test results are contradictory, making treatment options difficult. Combining quantitative tests and self-reported scales may facilitate physicians in planning EDS care with patients and families. CITATION: Sansone VA, Proserpio P, Mauro L, et al. Assessment of self-reported and objective daytime sleepiness in adult-onset myotonic dystrophy type 1. J Clin Sleep Med. 2021;17(12):2383–2391. |
| تدمد: | 1550-9397 1550-9389 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361d7a051895aae8fb860bba61ef6f48 https://doi.org/10.5664/jcsm.9438 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....361d7a051895aae8fb860bba61ef6f48 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15509397 15509389 |
|---|