Half-molar sodium lactate infusion to prevent intracranial hypertensive episodes in severe traumatic brain injured patients: a randomized controlled trial
| العنوان: | Half-molar sodium lactate infusion to prevent intracranial hypertensive episodes in severe traumatic brain injured patients: a randomized controlled trial |
|---|---|
| المؤلفون: | Gilles Francony, Jean François Payen, Jean Christophe Orban, Robin Legrand, Hubert Roth, Carole Ichai, Hervé Quintard, Xavier Leverve |
| المساهمون: | Service de réanimation, Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital St Roch, ANTE-INSERM U836, équipe 5, Neuroimagerie fonctionnelle et perfusion cérébrale, CIC - Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Anesthésie Réanimation, CHU Grenoble-Hôpital Michallon-CHU Grenoble-Hôpital Michallon, Centre Hospitalier Universitaire de Nice (CHU Nice), Institut de pharmacologie moléculaire et cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Pôle Anesthésie Réanimation, Centre Hospitalier Universitaire [Grenoble] (CHU) |
| المصدر: | Intensive Care Medicine Intensive Care Medicine, Springer Verlag, 2013, 39 (8), pp.1413-1422. ⟨10.1007/s00134-013-2978-9⟩ |
| بيانات النشر: | Springer Science and Business Media LLC, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, Adolescent, Traumatic brain injury, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Critical Care and Intensive Care Medicine, law.invention, Sodium Lactate, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, Injury Severity Score, 0302 clinical medicine, Chlorides, Double-Blind Method, Randomized controlled trial, law, Osmotherapy, Sodium lactate, medicine, Humans, Prospective Studies, Infusions, Intravenous, Prospective cohort study, Saline, ComputingMilieux_MISCELLANEOUS, Aged, Intracranial pressure, business.industry, Sodium, 030208 emergency & critical care medicine, Middle Aged, medicine.disease, Body Fluids, nervous system diseases, 3. Good health, chemistry, Brain Injuries, Anesthesia, Female, Intracranial Hypertension, business, 030217 neurology & neurosurgery |
| الوصف: | Preventive treatments of traumatic intracranial hypertension are not yet established. We aimed to compare the efficiency of half-molar sodium lactate (SL) versus saline serum solutions in preventing episodes of raised intracranial pressure (ICP) in patients with severe traumatic brain injury (TBI).This was a double-blind, randomized controlled trial including 60 patients with severe TBI requiring ICP monitoring. Patients were randomly allocated to receive a 48-h continuous infusion at 0.5 ml/kg/h of either SL (SL group) or isotonic saline solution (control group) within the first 12 h post-trauma. Serial measurements of ICP, as well as fluid, sodium, and chloride balance were performed over the 48-h study period. The primary outcome was the number of raised ICP (≥20 mmHg) requiring a specific treatment.Raised ICP episodes were reduced in the SL group as compared to the control group within the 48-h study period: 23 versus 53 episodes, respectively (p 0.05). The proportion of patients presenting raised ICP episodes was smaller in the SL group than in the saline group: 11 (36 %) versus 20 patients (66 %) (p 0.05). Cumulative 48-h fluid and chloride balances were reduced in the SL group compared to the control group (both p 0.01).A 48-h infusion of SL decreased the occurrence of raised ICP episodes in patients with severe TBI, while reducing fluid and chloride balances. These findings suggest that SL solution could be considered as an alternative treatment to prevent raised ICP following severe TBI. |
| تدمد: | 1432-1238 0342-4642 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363e8bf747859c64ee28d6a3734fb62c https://doi.org/10.1007/s00134-013-2978-9 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....363e8bf747859c64ee28d6a3734fb62c |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14321238 03424642 |
|---|