Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial
| العنوان: | Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial |
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| المؤلفون: | Bong Hyeon Kye, Jeong Meen Seo, Joo Yun Kim, Na Young Sung, Sung Bum Kang, Heung Kwon Oh, Yong Beom Cho, In Ja Park, Jae Hun Sim, Jung Lyoul Lee, In Kyu Lee, You Tae Kim, Ju Hoon Lee |
| المصدر: | Journal of Clinical Medicine Volume 9 Issue 7 Journal of Clinical Medicine, Vol 9, Iss 2181, p 2181 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Randomization, Colorectal cancer, Placebo-controlled study, lcsh:Medicine, Gut flora, Placebo, Gastroenterology, Article, law.invention, 03 medical and health sciences, Probiotic, 0302 clinical medicine, anti-bacterial agents, law, Internal medicine, medicine, 030304 developmental biology, Bifidobacterium, gastrointestinal microbiome, 0303 health sciences, biology, business.industry, lcsh:R, Zonulin, General Medicine, medicine.disease, biology.organism_classification, quality of life, 030220 oncology & carcinogenesis, treatment outcome, sigmoid neoplasms, business |
| الوصف: | We investigated microbiota changes following surgical colon cancer resection and evaluate effects of probiotics on microbiota and surgical recovery. This randomized double-blind trial was performed at four medical centers in South Korea. Of 68 patients expected to undergo anterior sigmoid colon cancer resection, 60 were eligible, of whom 29 and 31 received probiotics and placebo, respectively, for four weeks, starting at one week preoperatively. Third- and/or fourth-week information on anterior resection syndrome (ARS), inflammatory markers, and quality of life was obtained. Stool sample analysis was conducted after randomization and bowel preparation and at three and four postoperative weeks. Bacteria were categorized into Set I (with probiotic effects) and II (colon cancer-associated). The probiotic group&rsquo s ARS score showed an improving trend (p = 0.063), particularly for flatus control (p = 0.030). Serum zonulin levels significantly decreased with probiotics. Probiotic ingestion resulted in compositional changes in gut microbiota greater increases and decreases in Set I and II bacteria, respectively, occurred with probiotics. Compositional increase in Set I bacteria was associated with reduced white blood cells, neutrophils, neutrophil-lymphocyte ratio, and zonulin. Bifidobacterium composition was negatively correlated with zonulin levels in the probiotic group. Probiotics improved postoperative flatus control and modified postoperative changes in microbiota and inflammatory markers. |
| وصف الملف: | application/pdf |
| تدمد: | 2077-0383 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367bc64a862c8f2b08b554016895c971 https://pubmed.ncbi.nlm.nih.gov/32664289 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....367bc64a862c8f2b08b554016895c971 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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