Deep Brain Stimulation and Cognitive Outcomes Among Patients With Parkinson’s Disease: A Historical Cohort Study
| العنوان: | Deep Brain Stimulation and Cognitive Outcomes Among Patients With Parkinson’s Disease: A Historical Cohort Study |
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| المؤلفون: | Martin M. Limback-Stokin, Kristin A. Kirlin, Janina Krell-Roesch, Stefanie N. Velgos, Mark K. Lyons, Kimberly Roesler, Yonas E. Geda, Allison Hansen, Shyamal H. Mehta |
| المصدر: | The Journal of Neuropsychiatry and Clinical Neurosciences. 31:196-200 |
| بيانات النشر: | American Psychiatric Association Publishing, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Parkinson's disease, Deep brain stimulation, Deep Brain Stimulation, medicine.medical_treatment, Disease, Neuropsychological Tests, Globus Pallidus, behavioral disciplines and activities, Motor symptoms, Cohort Studies, 03 medical and health sciences, Cognition, 0302 clinical medicine, Physical medicine and rehabilitation, Subthalamic Nucleus, Humans, Medicine, Effective treatment, Aged, business.industry, Parkinson Disease, Middle Aged, medicine.disease, nervous system diseases, Psychiatry and Mental health, surgical procedures, operative, 030104 developmental biology, nervous system, Female, Neurology (clinical), business, therapeutics, 030217 neurology & neurosurgery, Historical Cohort |
| الوصف: | Deep brain stimulation (DBS) is an effective treatment for motor symptoms of Parkinson's disease; however, there is conflicting literature about the effect of DBS on cognitive function. The authors conducted a historical cohort study involving patients with Parkinson's disease who underwent DBS of the globus pallidus pars interna (GPi; N=12) or subthalamic nucleus (STN; N=17).The authors investigated differences in four neuropsychological test scores at 6 months post-DBS (follow-up) as compared with baseline (i.e., Boston Naming Test, WAIS Verbal Comprehension Index [WAIS-VCI], Working Memory Index [WAIS-WMI], and Processing Speed Index [WAIS-PSI]).GPi DBS patients showed no difference between baseline and follow-up on any neuropsychological test. STN DBS patients had lower scores indicating decreased performance at follow-up as compared with baseline on WAIS-PSI (mean [SD], 91.47 [10.42] versus 81.65 [12.03]; p=0.03). There was a significant (p=0.008) difference between the change in baseline to follow-up scores on the WAIS-VCI for the STN DBS and GPi DBS groups (i.e., STN DBS patients scored lower at the 6-month follow-up compared with baseline, whereas GPi DBS patients scored higher).GPi may be a preferred target for DBS in patients with Parkinson's disease when considering cognitive outcomes. |
| تدمد: | 1545-7222 0895-0172 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369b1e4c2d8391d76b4b2d5a2c6b9640 https://doi.org/10.1176/appi.neuropsych.18050118 |
| رقم الأكسشن: | edsair.doi.dedup.....369b1e4c2d8391d76b4b2d5a2c6b9640 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15457222 08950172 |
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