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Recurrent Miscarriage and Micro-RNA Among North Indian Women

التفاصيل البيبلوغرافية
العنوان: Recurrent Miscarriage and Micro-RNA Among North Indian Women
المؤلفون: Farah Parveen, Suraksha Agrawal
المصدر: Reproductive Sciences. 22:410-415
بيانات النشر: Springer Science and Business Media LLC, 2015.
سنة النشر: 2015
مصطلحات موضوعية: Abortion, Habitual, Heterozygote, medicine.medical_specialty, dbSNP, India, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Gastroenterology, Gene Frequency, Pregnancy, Risk Factors, Internal medicine, Genotype, Recurrent miscarriage, Odds Ratio, medicine, Humans, Genetic Predisposition to Disease, Allele, Genetic Association Studies, Homozygote, Obstetrics and Gynecology, Original Articles, Odds ratio, medicine.disease, Confidence interval, MicroRNAs, Phenotype, Haplotypes, Case-Control Studies, Immunology, Female, Restriction fragment length polymorphism
الوصف: Micro-RNAs (miRNAs) regulate diverse cellular processes such as cell differentiation, proliferation and apoptosis. Mutation in miRNAs results in various pathological conditions such as inflammation, viral infections, neurodegeneration, autoimmunity, and so on. We have evaluated the association of miR-146aC > G (rs2910164), miR-149T > C (rs2292832), miR-196a2T > C (rs11614913), and miR-499A > G (rs3746444) among patients with recurrent miscarriage (RM) and controls from North India. All the 200 patients with RM reported to experience at least 3 unexplained miscarriages before 20th week of gestation. Three hundred fertile women with no history of RMs were taken as controls. Both patients and controls were genotyped by the polymerase chain reaction amplification followed by restriction fragment length polymorphism. Variant alleles and genotypes of miR-499 A > G (Single Nucleotide Polymorphism Database [dbSNP] ID rs3746444) were found to be significant risks associated with patients having RM (odds ratio [OR] = 1.98; 95% confidence interval [CI] = 1.40-2.81; P value = .0001) and controls (OR = 3.64; 95% CI = 1.33-9.94; P value = .0109). A significant susceptible effect was found at allelic level in miR-196aT > C (dbSNP ID rs11614913) and miR-499 A > G (dbSNP ID rs3746444).
تدمد: 1933-7205
1933-7191
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369d4fdb99d23ccb8047669f2851cc79
https://doi.org/10.1177/1933719114529376
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....369d4fdb99d23ccb8047669f2851cc79
قاعدة البيانات: OpenAIRE
الوصف
تدمد:19337205
19337191